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Hypertension, diabetes mellitus, and cerebrovascular disease predispose to a more severe outcome of COVID-19

INTRODUCTION: The world is currently facing the pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The total number of cases of coronavirus disease 2019 (COVID-19) is rising daily and no vaccine has yet been approved. While the pathophysiology behind the virus is still being s...

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Autores principales: Ramphul, Kamleshun, Lohana, Petras, Ramphul, Yogeshwaree, Park, Yun, Mejias, Stephanie, Dhillon, Balkiranjit Kaur, Sombans, Shaheen, Verma, Renuka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117084/
https://www.ncbi.nlm.nih.gov/pubmed/34027212
http://dx.doi.org/10.5114/amsad.2021.105255
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author Ramphul, Kamleshun
Lohana, Petras
Ramphul, Yogeshwaree
Park, Yun
Mejias, Stephanie
Dhillon, Balkiranjit Kaur
Sombans, Shaheen
Verma, Renuka
author_facet Ramphul, Kamleshun
Lohana, Petras
Ramphul, Yogeshwaree
Park, Yun
Mejias, Stephanie
Dhillon, Balkiranjit Kaur
Sombans, Shaheen
Verma, Renuka
author_sort Ramphul, Kamleshun
collection PubMed
description INTRODUCTION: The world is currently facing the pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The total number of cases of coronavirus disease 2019 (COVID-19) is rising daily and no vaccine has yet been approved. While the pathophysiology behind the virus is still being studied, many possible several risk factors using small sample sizes have been found. MATERIAL AND METHODS: We conducted a pooled analysis using several databases such as Medline, Scopus, Wangfang, Web of Science, Research Square, medrxiv, and Google Scholar to identify studies reporting severe and non-severe groups of COVID-19 patients. The odds ratios as well as the 95% confidence intervals for hypertension, diabetes, and cerebrovascular disease leading to severe COVID-19 were calculated using R-software. RESULTS: Fifty-three articles were used for our analysis and they involved 30,935 confirmed cases of COVID-19 from several countries across the world. The odds ratio for severe COVID-19 in hypertensive patients, diabetics, and patients with a history of cerebrovascular disease was 2.58 (95% confidence interval (CI): 2.16–3.08, from 53 studies), 2.17 (95% CI: 1.72–2.74, from 44 studies), and 2.63 (95% CI: 1.80–3.85, from 25 studies), respectively. CONCLUSIONS: Our analysis confirms that patients with hypertension, diabetes, or cerebrovascular disease are at a higher risk of a severe outcome of COVID-19. It is thus vital for physicians to identify the main risk factors for a severe outcome of this disease.
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spelling pubmed-81170842021-05-20 Hypertension, diabetes mellitus, and cerebrovascular disease predispose to a more severe outcome of COVID-19 Ramphul, Kamleshun Lohana, Petras Ramphul, Yogeshwaree Park, Yun Mejias, Stephanie Dhillon, Balkiranjit Kaur Sombans, Shaheen Verma, Renuka Arch Med Sci Atheroscler Dis Clinical Research INTRODUCTION: The world is currently facing the pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The total number of cases of coronavirus disease 2019 (COVID-19) is rising daily and no vaccine has yet been approved. While the pathophysiology behind the virus is still being studied, many possible several risk factors using small sample sizes have been found. MATERIAL AND METHODS: We conducted a pooled analysis using several databases such as Medline, Scopus, Wangfang, Web of Science, Research Square, medrxiv, and Google Scholar to identify studies reporting severe and non-severe groups of COVID-19 patients. The odds ratios as well as the 95% confidence intervals for hypertension, diabetes, and cerebrovascular disease leading to severe COVID-19 were calculated using R-software. RESULTS: Fifty-three articles were used for our analysis and they involved 30,935 confirmed cases of COVID-19 from several countries across the world. The odds ratio for severe COVID-19 in hypertensive patients, diabetics, and patients with a history of cerebrovascular disease was 2.58 (95% confidence interval (CI): 2.16–3.08, from 53 studies), 2.17 (95% CI: 1.72–2.74, from 44 studies), and 2.63 (95% CI: 1.80–3.85, from 25 studies), respectively. CONCLUSIONS: Our analysis confirms that patients with hypertension, diabetes, or cerebrovascular disease are at a higher risk of a severe outcome of COVID-19. It is thus vital for physicians to identify the main risk factors for a severe outcome of this disease. Termedia Publishing House 2021-04-12 /pmc/articles/PMC8117084/ /pubmed/34027212 http://dx.doi.org/10.5114/amsad.2021.105255 Text en Copyright: © 2021 Termedia & Banach https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Clinical Research
Ramphul, Kamleshun
Lohana, Petras
Ramphul, Yogeshwaree
Park, Yun
Mejias, Stephanie
Dhillon, Balkiranjit Kaur
Sombans, Shaheen
Verma, Renuka
Hypertension, diabetes mellitus, and cerebrovascular disease predispose to a more severe outcome of COVID-19
title Hypertension, diabetes mellitus, and cerebrovascular disease predispose to a more severe outcome of COVID-19
title_full Hypertension, diabetes mellitus, and cerebrovascular disease predispose to a more severe outcome of COVID-19
title_fullStr Hypertension, diabetes mellitus, and cerebrovascular disease predispose to a more severe outcome of COVID-19
title_full_unstemmed Hypertension, diabetes mellitus, and cerebrovascular disease predispose to a more severe outcome of COVID-19
title_short Hypertension, diabetes mellitus, and cerebrovascular disease predispose to a more severe outcome of COVID-19
title_sort hypertension, diabetes mellitus, and cerebrovascular disease predispose to a more severe outcome of covid-19
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117084/
https://www.ncbi.nlm.nih.gov/pubmed/34027212
http://dx.doi.org/10.5114/amsad.2021.105255
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