Cargando…

Epigenetic Regulation of Epithelial to Mesenchymal Transition in the Cancer Metastatic Cascade: Implications for Cancer Therapy

Metastasis is the end stage of cancer progression and the direct cause of most cancer-related deaths. The spreading of cancer cells from the primary site to distant organs is a multistep process known as the metastatic cascade, including local invasion, intravasation, survival in the circulation, ex...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Qiu-Luo, Luo, Maochao, Huang, Canhua, Chen, Hai-Ning, Zhou, Zong-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117142/
https://www.ncbi.nlm.nih.gov/pubmed/33996581
http://dx.doi.org/10.3389/fonc.2021.657546
_version_ 1783691542456696832
author Liu, Qiu-Luo
Luo, Maochao
Huang, Canhua
Chen, Hai-Ning
Zhou, Zong-Guang
author_facet Liu, Qiu-Luo
Luo, Maochao
Huang, Canhua
Chen, Hai-Ning
Zhou, Zong-Guang
author_sort Liu, Qiu-Luo
collection PubMed
description Metastasis is the end stage of cancer progression and the direct cause of most cancer-related deaths. The spreading of cancer cells from the primary site to distant organs is a multistep process known as the metastatic cascade, including local invasion, intravasation, survival in the circulation, extravasation, and colonization. Each of these steps is driven by the acquisition of genetic and/or epigenetic alterations within cancer cells, leading to subsequent transformation of metastatic cells. Epithelial–mesenchymal transition (EMT), a cellular process mediating the conversion of cell from epithelial to mesenchymal phenotype, and its reverse transformation, termed mesenchymal–epithelial transition (MET), together endow metastatic cells with traits needed to generate overt metastases in different scenarios. The dynamic shift between these two phenotypes and their transitional state, termed partial EMT, emphasizes the plasticity of EMT. Recent advances attributed this plasticity to epigenetic regulation, which has implications for the therapeutic targeting of cancer metastasis. In this review, we will discuss the association between epigenetic events and the multifaceted nature of EMT, which may provide insights into the steps of the cancer metastatic cascade.
format Online
Article
Text
id pubmed-8117142
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-81171422021-05-14 Epigenetic Regulation of Epithelial to Mesenchymal Transition in the Cancer Metastatic Cascade: Implications for Cancer Therapy Liu, Qiu-Luo Luo, Maochao Huang, Canhua Chen, Hai-Ning Zhou, Zong-Guang Front Oncol Oncology Metastasis is the end stage of cancer progression and the direct cause of most cancer-related deaths. The spreading of cancer cells from the primary site to distant organs is a multistep process known as the metastatic cascade, including local invasion, intravasation, survival in the circulation, extravasation, and colonization. Each of these steps is driven by the acquisition of genetic and/or epigenetic alterations within cancer cells, leading to subsequent transformation of metastatic cells. Epithelial–mesenchymal transition (EMT), a cellular process mediating the conversion of cell from epithelial to mesenchymal phenotype, and its reverse transformation, termed mesenchymal–epithelial transition (MET), together endow metastatic cells with traits needed to generate overt metastases in different scenarios. The dynamic shift between these two phenotypes and their transitional state, termed partial EMT, emphasizes the plasticity of EMT. Recent advances attributed this plasticity to epigenetic regulation, which has implications for the therapeutic targeting of cancer metastasis. In this review, we will discuss the association between epigenetic events and the multifaceted nature of EMT, which may provide insights into the steps of the cancer metastatic cascade. Frontiers Media S.A. 2021-04-29 /pmc/articles/PMC8117142/ /pubmed/33996581 http://dx.doi.org/10.3389/fonc.2021.657546 Text en Copyright © 2021 Liu, Luo, Huang, Chen and Zhou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Liu, Qiu-Luo
Luo, Maochao
Huang, Canhua
Chen, Hai-Ning
Zhou, Zong-Guang
Epigenetic Regulation of Epithelial to Mesenchymal Transition in the Cancer Metastatic Cascade: Implications for Cancer Therapy
title Epigenetic Regulation of Epithelial to Mesenchymal Transition in the Cancer Metastatic Cascade: Implications for Cancer Therapy
title_full Epigenetic Regulation of Epithelial to Mesenchymal Transition in the Cancer Metastatic Cascade: Implications for Cancer Therapy
title_fullStr Epigenetic Regulation of Epithelial to Mesenchymal Transition in the Cancer Metastatic Cascade: Implications for Cancer Therapy
title_full_unstemmed Epigenetic Regulation of Epithelial to Mesenchymal Transition in the Cancer Metastatic Cascade: Implications for Cancer Therapy
title_short Epigenetic Regulation of Epithelial to Mesenchymal Transition in the Cancer Metastatic Cascade: Implications for Cancer Therapy
title_sort epigenetic regulation of epithelial to mesenchymal transition in the cancer metastatic cascade: implications for cancer therapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117142/
https://www.ncbi.nlm.nih.gov/pubmed/33996581
http://dx.doi.org/10.3389/fonc.2021.657546
work_keys_str_mv AT liuqiuluo epigeneticregulationofepithelialtomesenchymaltransitioninthecancermetastaticcascadeimplicationsforcancertherapy
AT luomaochao epigeneticregulationofepithelialtomesenchymaltransitioninthecancermetastaticcascadeimplicationsforcancertherapy
AT huangcanhua epigeneticregulationofepithelialtomesenchymaltransitioninthecancermetastaticcascadeimplicationsforcancertherapy
AT chenhaining epigeneticregulationofepithelialtomesenchymaltransitioninthecancermetastaticcascadeimplicationsforcancertherapy
AT zhouzongguang epigeneticregulationofepithelialtomesenchymaltransitioninthecancermetastaticcascadeimplicationsforcancertherapy