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Mechanisms of Apoptosis-Related Long Non-coding RNAs in Ovarian Cancer

Ovarian cancer is a health-threatening malignancy of ovary in female reproductive systems and one of the most common gynecological malignancies worldwide. Due to rare early symptoms, ovarian cancers are often diagnosed at advanced stages and exhibit poor prognosis. Thus, efforts have been paid to de...

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Autores principales: Takeiwa, Toshihiko, Ikeda, Kazuhiro, Horie-Inoue, Kuniko, Inoue, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117355/
https://www.ncbi.nlm.nih.gov/pubmed/33996797
http://dx.doi.org/10.3389/fcell.2021.641963
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author Takeiwa, Toshihiko
Ikeda, Kazuhiro
Horie-Inoue, Kuniko
Inoue, Satoshi
author_facet Takeiwa, Toshihiko
Ikeda, Kazuhiro
Horie-Inoue, Kuniko
Inoue, Satoshi
author_sort Takeiwa, Toshihiko
collection PubMed
description Ovarian cancer is a health-threatening malignancy of ovary in female reproductive systems and one of the most common gynecological malignancies worldwide. Due to rare early symptoms, ovarian cancers are often diagnosed at advanced stages and exhibit poor prognosis. Thus, efforts have been paid to develop alternative diagnostic and therapeutic strategies for the disease. Recent studies have presented that some long non-coding RNAs (lncRNAs) play roles in apoptosis of ovarian cancer cells through various mechanisms involved in the regulation of transcription factors, histone modification complexes, miRNAs, and protein stability. Because evasion of apoptosis in cancer cells facilitates to promote tumor progression and therapy resistance, apoptosis regulatory mechanisms of lncRNAs may be promising new targets in ovarian cancer. In this review, we introduce the recent findings in regard to the molecular mechanisms of apoptosis-related lncRNAs in ovarian cancer cells.
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spelling pubmed-81173552021-05-14 Mechanisms of Apoptosis-Related Long Non-coding RNAs in Ovarian Cancer Takeiwa, Toshihiko Ikeda, Kazuhiro Horie-Inoue, Kuniko Inoue, Satoshi Front Cell Dev Biol Cell and Developmental Biology Ovarian cancer is a health-threatening malignancy of ovary in female reproductive systems and one of the most common gynecological malignancies worldwide. Due to rare early symptoms, ovarian cancers are often diagnosed at advanced stages and exhibit poor prognosis. Thus, efforts have been paid to develop alternative diagnostic and therapeutic strategies for the disease. Recent studies have presented that some long non-coding RNAs (lncRNAs) play roles in apoptosis of ovarian cancer cells through various mechanisms involved in the regulation of transcription factors, histone modification complexes, miRNAs, and protein stability. Because evasion of apoptosis in cancer cells facilitates to promote tumor progression and therapy resistance, apoptosis regulatory mechanisms of lncRNAs may be promising new targets in ovarian cancer. In this review, we introduce the recent findings in regard to the molecular mechanisms of apoptosis-related lncRNAs in ovarian cancer cells. Frontiers Media S.A. 2021-04-29 /pmc/articles/PMC8117355/ /pubmed/33996797 http://dx.doi.org/10.3389/fcell.2021.641963 Text en Copyright © 2021 Takeiwa, Ikeda, Horie-Inoue and Inoue. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Takeiwa, Toshihiko
Ikeda, Kazuhiro
Horie-Inoue, Kuniko
Inoue, Satoshi
Mechanisms of Apoptosis-Related Long Non-coding RNAs in Ovarian Cancer
title Mechanisms of Apoptosis-Related Long Non-coding RNAs in Ovarian Cancer
title_full Mechanisms of Apoptosis-Related Long Non-coding RNAs in Ovarian Cancer
title_fullStr Mechanisms of Apoptosis-Related Long Non-coding RNAs in Ovarian Cancer
title_full_unstemmed Mechanisms of Apoptosis-Related Long Non-coding RNAs in Ovarian Cancer
title_short Mechanisms of Apoptosis-Related Long Non-coding RNAs in Ovarian Cancer
title_sort mechanisms of apoptosis-related long non-coding rnas in ovarian cancer
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117355/
https://www.ncbi.nlm.nih.gov/pubmed/33996797
http://dx.doi.org/10.3389/fcell.2021.641963
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