Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesis

BACKGROUND: Both advanced glycation end products (AGEs) and AGE-mediated M1 macrophage polarization contribute to bone marrow mesenchymal stem cell (BMSC) dysfunction, leading to impaired bone regeneration in type 1 diabetes mellitus (T1DM). Adrenomedullin 2 (ADM2), an endogenous bioactive peptide b...

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Detalles Bibliográficos
Autores principales: Wang, Feng, Kong, Lingchi, Wang, Wenbo, Shi, Li, Wang, Mengwei, Chai, Yimin, Xu, Jia, Kang, Qinglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117361/
https://www.ncbi.nlm.nih.gov/pubmed/33985585
http://dx.doi.org/10.1186/s13287-021-02368-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117361/
https://www.ncbi.nlm.nih.gov/pubmed/33985585
http://dx.doi.org/10.1186/s13287-021-02368-9

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