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Novel Trifluoromethyl Pyrimidinone Compounds With Activity Against Mycobacterium tuberculosis

The identification and development of new anti-tubercular agents are a priority research area. We identified the trifluoromethyl pyrimidinone series of compounds in a whole-cell screen against Mycobacterium tuberculosis. Fifteen primary hits had minimum inhibitory concentrations (MICs) with good pot...

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Detalles Bibliográficos
Autores principales:	Hembre, Erik, Early, Julie V., Odingo, Joshua, Shelton, Catherine, Anoshchenko, Olena, Guzman, Junitta, Flint, Lindsay, Dennison, Devon, McNeil, Matthew B., Korkegian, Aaron, Ovechkina, Yulia, Ornstein, Paul, Masquelin, Thierry, Hipskind, Philip A., Parish, Tanya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117417/ https://www.ncbi.nlm.nih.gov/pubmed/33996738 http://dx.doi.org/10.3389/fchem.2021.613349

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