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De novo Portal Vein Thrombosis in Non-Cirrhotic Non-Alcoholic Fatty Liver Disease: A 9-Year Prospective Cohort Study

Background and Aims: Approximately 30–40% of portal vein thrombosis (PVT) remains of unknown origin. The association between non-alcoholic fatty liver disease (NAFLD) and PVT is a matter of debate. This study aimed to investigate the association between PVT and NAFLD. Methods: We included 94 out of...

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Autores principales: Abdel-Razik, Ahmed, Mousa, Nasser, Shabana, Walaa, Yassen, Ahmed H., Abdelsalam, Mostafa, Wahba, Mohamed M., Helmy, Eman Mohamed, Tawfik, Ahmed M., Zalata, Khaled, Hasan, Ahmad S., Elhelaly, Rania, Elzehery, Rasha, Fathy, Aya Ahmed, El-Wakeel, Niveen, Eldars, Waleed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117420/
https://www.ncbi.nlm.nih.gov/pubmed/33996858
http://dx.doi.org/10.3389/fmed.2021.650818
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author Abdel-Razik, Ahmed
Mousa, Nasser
Shabana, Walaa
Yassen, Ahmed H.
Abdelsalam, Mostafa
Wahba, Mohamed M.
Helmy, Eman Mohamed
Tawfik, Ahmed M.
Zalata, Khaled
Hasan, Ahmad S.
Elhelaly, Rania
Elzehery, Rasha
Fathy, Aya Ahmed
El-Wakeel, Niveen
Eldars, Waleed
author_facet Abdel-Razik, Ahmed
Mousa, Nasser
Shabana, Walaa
Yassen, Ahmed H.
Abdelsalam, Mostafa
Wahba, Mohamed M.
Helmy, Eman Mohamed
Tawfik, Ahmed M.
Zalata, Khaled
Hasan, Ahmad S.
Elhelaly, Rania
Elzehery, Rasha
Fathy, Aya Ahmed
El-Wakeel, Niveen
Eldars, Waleed
author_sort Abdel-Razik, Ahmed
collection PubMed
description Background and Aims: Approximately 30–40% of portal vein thrombosis (PVT) remains of unknown origin. The association between non-alcoholic fatty liver disease (NAFLD) and PVT is a matter of debate. This study aimed to investigate the association between PVT and NAFLD. Methods: We included 94 out of 105 consecutive NAFLD patients in this prospective cohort study in addition to 94 from the healthy control group. We evaluated biochemical, clinical, immunological, and histopathological parameters; waist circumference (WC); leptin; adiponectin; and leptin/adiponectin ratio (LAR) for all participants at baseline and every 3 years thereafter. We described the characteristics of participants at baseline and showed individual WC, LAR, and PVT characteristics. Potential parameters to predict PVT development within 9 years were determined. Results: PVT developed in eight (8.5%) patients, mainly in the portal trunk. Univariate analysis showed three PVT-associated factors: diabetes mellitus (P = 0.013), WC (P < 0.001), and LAR (P = 0.002). After adjusting multiple confounding variables, the multivariate model showed that the only significant variables were WC and LAR. By applying the receiver operating characteristic curve, WC had 98.8% specificity, 87.5% sensitivity, and 0.894 area under the curve (AUC) for prediction of PVT (P < 0.001) at cutoff values of > 105 cm. In comparison, LAR had 60.5% specificity, 87.5% sensitivity, and 0.805 AUC for PVT prediction (P < 0.001) at cutoff values of >7.5. Conclusions: This study suggests that increased central obesity and LAR were independently associated with PVT development in non-cirrhotic NAFLD patients, and they should be considered risk factors that may participate in PVT multifactorial pathogenesis.
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spelling pubmed-81174202021-05-14 De novo Portal Vein Thrombosis in Non-Cirrhotic Non-Alcoholic Fatty Liver Disease: A 9-Year Prospective Cohort Study Abdel-Razik, Ahmed Mousa, Nasser Shabana, Walaa Yassen, Ahmed H. Abdelsalam, Mostafa Wahba, Mohamed M. Helmy, Eman Mohamed Tawfik, Ahmed M. Zalata, Khaled Hasan, Ahmad S. Elhelaly, Rania Elzehery, Rasha Fathy, Aya Ahmed El-Wakeel, Niveen Eldars, Waleed Front Med (Lausanne) Medicine Background and Aims: Approximately 30–40% of portal vein thrombosis (PVT) remains of unknown origin. The association between non-alcoholic fatty liver disease (NAFLD) and PVT is a matter of debate. This study aimed to investigate the association between PVT and NAFLD. Methods: We included 94 out of 105 consecutive NAFLD patients in this prospective cohort study in addition to 94 from the healthy control group. We evaluated biochemical, clinical, immunological, and histopathological parameters; waist circumference (WC); leptin; adiponectin; and leptin/adiponectin ratio (LAR) for all participants at baseline and every 3 years thereafter. We described the characteristics of participants at baseline and showed individual WC, LAR, and PVT characteristics. Potential parameters to predict PVT development within 9 years were determined. Results: PVT developed in eight (8.5%) patients, mainly in the portal trunk. Univariate analysis showed three PVT-associated factors: diabetes mellitus (P = 0.013), WC (P < 0.001), and LAR (P = 0.002). After adjusting multiple confounding variables, the multivariate model showed that the only significant variables were WC and LAR. By applying the receiver operating characteristic curve, WC had 98.8% specificity, 87.5% sensitivity, and 0.894 area under the curve (AUC) for prediction of PVT (P < 0.001) at cutoff values of > 105 cm. In comparison, LAR had 60.5% specificity, 87.5% sensitivity, and 0.805 AUC for PVT prediction (P < 0.001) at cutoff values of >7.5. Conclusions: This study suggests that increased central obesity and LAR were independently associated with PVT development in non-cirrhotic NAFLD patients, and they should be considered risk factors that may participate in PVT multifactorial pathogenesis. Frontiers Media S.A. 2021-04-29 /pmc/articles/PMC8117420/ /pubmed/33996858 http://dx.doi.org/10.3389/fmed.2021.650818 Text en Copyright © 2021 Abdel-Razik, Mousa, Shabana, Yassen, Abdelsalam, Wahba, Helmy, Tawfik, Zalata, Hasan, Elhelaly, Elzehery, Fathy, El-Wakeel and Eldars. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Abdel-Razik, Ahmed
Mousa, Nasser
Shabana, Walaa
Yassen, Ahmed H.
Abdelsalam, Mostafa
Wahba, Mohamed M.
Helmy, Eman Mohamed
Tawfik, Ahmed M.
Zalata, Khaled
Hasan, Ahmad S.
Elhelaly, Rania
Elzehery, Rasha
Fathy, Aya Ahmed
El-Wakeel, Niveen
Eldars, Waleed
De novo Portal Vein Thrombosis in Non-Cirrhotic Non-Alcoholic Fatty Liver Disease: A 9-Year Prospective Cohort Study
title De novo Portal Vein Thrombosis in Non-Cirrhotic Non-Alcoholic Fatty Liver Disease: A 9-Year Prospective Cohort Study
title_full De novo Portal Vein Thrombosis in Non-Cirrhotic Non-Alcoholic Fatty Liver Disease: A 9-Year Prospective Cohort Study
title_fullStr De novo Portal Vein Thrombosis in Non-Cirrhotic Non-Alcoholic Fatty Liver Disease: A 9-Year Prospective Cohort Study
title_full_unstemmed De novo Portal Vein Thrombosis in Non-Cirrhotic Non-Alcoholic Fatty Liver Disease: A 9-Year Prospective Cohort Study
title_short De novo Portal Vein Thrombosis in Non-Cirrhotic Non-Alcoholic Fatty Liver Disease: A 9-Year Prospective Cohort Study
title_sort de novo portal vein thrombosis in non-cirrhotic non-alcoholic fatty liver disease: a 9-year prospective cohort study
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117420/
https://www.ncbi.nlm.nih.gov/pubmed/33996858
http://dx.doi.org/10.3389/fmed.2021.650818
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