Cargando…

Selenium-related nutritional status in patients with common variable immunodeficiency: association with oxidative stress and atherosclerosis risk

BACKGROUND: Common variable immunodeficiency (CVID) is an inborn errors of immunity, that leads to recurrent chronic infections and autoimmune/ inflammatory diseases and neoplasms. It is considered that these condition is related to persistent this immune-inflammatory stimulation and increased oxida...

Descripción completa

Detalles Bibliográficos
Autores principales: Andrade, Itana Gomes Alves, de Souza, Fabíola Isabel Suano, Fonseca, Fernando Luiz Affonso, Aranda, Carolina Sanchez, Sarni, Roseli Oselka Saccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117617/
https://www.ncbi.nlm.nih.gov/pubmed/33985428
http://dx.doi.org/10.1186/s12865-021-00425-9
_version_ 1783691618049589248
author Andrade, Itana Gomes Alves
de Souza, Fabíola Isabel Suano
Fonseca, Fernando Luiz Affonso
Aranda, Carolina Sanchez
Sarni, Roseli Oselka Saccardo
author_facet Andrade, Itana Gomes Alves
de Souza, Fabíola Isabel Suano
Fonseca, Fernando Luiz Affonso
Aranda, Carolina Sanchez
Sarni, Roseli Oselka Saccardo
author_sort Andrade, Itana Gomes Alves
collection PubMed
description BACKGROUND: Common variable immunodeficiency (CVID) is an inborn errors of immunity, that leads to recurrent chronic infections and autoimmune/ inflammatory diseases and neoplasms. It is considered that these condition is related to persistent this immune-inflammatory stimulation and increased oxidative stress. A positive impact on the survival of patients with an inborn error of immunity was observed with advanced clinical care protocols, thus raising concerns about the risk of developing other associated chronic diseases, such as atherosclerosis. Studies suggest that selenium (Se) is a protective trace element against damage caused by oxidative stress. Thus, it is postulated that adequate consumption reduces the risk of some chronic diseases. RESULTS: Se median levels (ug/L) [45.6 (37.3–56.2) vs. 57.8 (46.0–66.0); p = 0.004] and GPX activity (U/L) [7682 (6548–8446) vs. 9284(8440–10,720); p = 0,002) were significantly lower in patients compared to controls. Inadequacy of Se levels was observed in 50% of the patients. There was a higher percentage of high values of C-reactive protein in the group of CVID patients compared to controls [8 (36.4%) vs. 2 (11.1%); p = 0.082]. Higher concentrations of oxidized LDL (45.3 mg/dL vs. 33.3 mg/dL; p = 0.016) and lower concentrations of Apo A-1 (98.5 mg/dL) vs. 117.0 mg/dL; p = 0.008) were observed in the CVID group compared to the control. There was a significant and positive correlation between Se plasma levels and apolipoprotein A-1 concentrations in CVID group (rho = 0.577; p = 0.001). Se values less than 46 μg / L (OR = 3.590; 95% CI 1.103 to 11.687; p = 0.034) and GPX activity below the 4th quartile (OR = 21.703; 95% CI 2.534 to 185.914; p = 0.005) were independently associated, after adjustment for age, overweight and dyslipidemia, with the CVID group (Table 5). CONCLUSION: This study showed an higher percentage of high us-CRP, lower values of plasma Se and GPX activity, higher concentrations of LDLox and lower levels of Apo A-1 in CVID patients in comparison to controls, suggesting oxidative stress and cardiovascular risk.These data point to the importance of assessing the Se status and cardiovascular risk in these patients.
format Online
Article
Text
id pubmed-8117617
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-81176172021-05-17 Selenium-related nutritional status in patients with common variable immunodeficiency: association with oxidative stress and atherosclerosis risk Andrade, Itana Gomes Alves de Souza, Fabíola Isabel Suano Fonseca, Fernando Luiz Affonso Aranda, Carolina Sanchez Sarni, Roseli Oselka Saccardo BMC Immunol Research BACKGROUND: Common variable immunodeficiency (CVID) is an inborn errors of immunity, that leads to recurrent chronic infections and autoimmune/ inflammatory diseases and neoplasms. It is considered that these condition is related to persistent this immune-inflammatory stimulation and increased oxidative stress. A positive impact on the survival of patients with an inborn error of immunity was observed with advanced clinical care protocols, thus raising concerns about the risk of developing other associated chronic diseases, such as atherosclerosis. Studies suggest that selenium (Se) is a protective trace element against damage caused by oxidative stress. Thus, it is postulated that adequate consumption reduces the risk of some chronic diseases. RESULTS: Se median levels (ug/L) [45.6 (37.3–56.2) vs. 57.8 (46.0–66.0); p = 0.004] and GPX activity (U/L) [7682 (6548–8446) vs. 9284(8440–10,720); p = 0,002) were significantly lower in patients compared to controls. Inadequacy of Se levels was observed in 50% of the patients. There was a higher percentage of high values of C-reactive protein in the group of CVID patients compared to controls [8 (36.4%) vs. 2 (11.1%); p = 0.082]. Higher concentrations of oxidized LDL (45.3 mg/dL vs. 33.3 mg/dL; p = 0.016) and lower concentrations of Apo A-1 (98.5 mg/dL) vs. 117.0 mg/dL; p = 0.008) were observed in the CVID group compared to the control. There was a significant and positive correlation between Se plasma levels and apolipoprotein A-1 concentrations in CVID group (rho = 0.577; p = 0.001). Se values less than 46 μg / L (OR = 3.590; 95% CI 1.103 to 11.687; p = 0.034) and GPX activity below the 4th quartile (OR = 21.703; 95% CI 2.534 to 185.914; p = 0.005) were independently associated, after adjustment for age, overweight and dyslipidemia, with the CVID group (Table 5). CONCLUSION: This study showed an higher percentage of high us-CRP, lower values of plasma Se and GPX activity, higher concentrations of LDLox and lower levels of Apo A-1 in CVID patients in comparison to controls, suggesting oxidative stress and cardiovascular risk.These data point to the importance of assessing the Se status and cardiovascular risk in these patients. BioMed Central 2021-05-13 /pmc/articles/PMC8117617/ /pubmed/33985428 http://dx.doi.org/10.1186/s12865-021-00425-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Andrade, Itana Gomes Alves
de Souza, Fabíola Isabel Suano
Fonseca, Fernando Luiz Affonso
Aranda, Carolina Sanchez
Sarni, Roseli Oselka Saccardo
Selenium-related nutritional status in patients with common variable immunodeficiency: association with oxidative stress and atherosclerosis risk
title Selenium-related nutritional status in patients with common variable immunodeficiency: association with oxidative stress and atherosclerosis risk
title_full Selenium-related nutritional status in patients with common variable immunodeficiency: association with oxidative stress and atherosclerosis risk
title_fullStr Selenium-related nutritional status in patients with common variable immunodeficiency: association with oxidative stress and atherosclerosis risk
title_full_unstemmed Selenium-related nutritional status in patients with common variable immunodeficiency: association with oxidative stress and atherosclerosis risk
title_short Selenium-related nutritional status in patients with common variable immunodeficiency: association with oxidative stress and atherosclerosis risk
title_sort selenium-related nutritional status in patients with common variable immunodeficiency: association with oxidative stress and atherosclerosis risk
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117617/
https://www.ncbi.nlm.nih.gov/pubmed/33985428
http://dx.doi.org/10.1186/s12865-021-00425-9
work_keys_str_mv AT andradeitanagomesalves seleniumrelatednutritionalstatusinpatientswithcommonvariableimmunodeficiencyassociationwithoxidativestressandatherosclerosisrisk
AT desouzafabiolaisabelsuano seleniumrelatednutritionalstatusinpatientswithcommonvariableimmunodeficiencyassociationwithoxidativestressandatherosclerosisrisk
AT fonsecafernandoluizaffonso seleniumrelatednutritionalstatusinpatientswithcommonvariableimmunodeficiencyassociationwithoxidativestressandatherosclerosisrisk
AT arandacarolinasanchez seleniumrelatednutritionalstatusinpatientswithcommonvariableimmunodeficiencyassociationwithoxidativestressandatherosclerosisrisk
AT sarniroselioselkasaccardo seleniumrelatednutritionalstatusinpatientswithcommonvariableimmunodeficiencyassociationwithoxidativestressandatherosclerosisrisk