Clinical efficacy of nitric oxide nasal spray (NONS) for the treatment of mild COVID-19 infection

Baek et al.(1) investigated the duration of COVID-19 virus shedding in infected patients and demonstrated that even in patients demonstrating prolonged viral clearance, the virus was no longer viable after 15 days post onset of symptoms. Our study aimed to measure whether nitric oxide nasal spray (N...

Descripción completa

Detalles Bibliográficos
Autores principales: Winchester, Stephen, John, Sarah, Jabbar, Kashif, John, Isaac
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Infection Association. Published by Elsevier Ltd. 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117664/
https://www.ncbi.nlm.nih.gov/pubmed/33992687
http://dx.doi.org/10.1016/j.jinf.2021.05.009
_version_ 1783691627903057920
author Winchester, Stephen
John, Sarah
Jabbar, Kashif
John, Isaac
author_facet Winchester, Stephen
John, Sarah
Jabbar, Kashif
John, Isaac
author_sort Winchester, Stephen
collection PubMed
description Baek et al.(1) investigated the duration of COVID-19 virus shedding in infected patients and demonstrated that even in patients demonstrating prolonged viral clearance, the virus was no longer viable after 15 days post onset of symptoms. Our study aimed to measure whether nitric oxide nasal spray (NONS) further accelerates this reduction in SARS-CoV-2 RNA load versus a control arm with saline spray. Our study recruited 80 participants who were divided into a NONS treatment arm or a placebo arm to test the efficacy of NONS as a treatment for mild COVID-19 infection.
format Online
Article
Text
id pubmed-8117664
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The British Infection Association. Published by Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-81176642021-05-13 Clinical efficacy of nitric oxide nasal spray (NONS) for the treatment of mild COVID-19 infection Winchester, Stephen John, Sarah Jabbar, Kashif John, Isaac J Infect Letter to the Editor Baek et al.(1) investigated the duration of COVID-19 virus shedding in infected patients and demonstrated that even in patients demonstrating prolonged viral clearance, the virus was no longer viable after 15 days post onset of symptoms. Our study aimed to measure whether nitric oxide nasal spray (NONS) further accelerates this reduction in SARS-CoV-2 RNA load versus a control arm with saline spray. Our study recruited 80 participants who were divided into a NONS treatment arm or a placebo arm to test the efficacy of NONS as a treatment for mild COVID-19 infection. The British Infection Association. Published by Elsevier Ltd. 2021-08 2021-05-13 /pmc/articles/PMC8117664/ /pubmed/33992687 http://dx.doi.org/10.1016/j.jinf.2021.05.009 Text en © 2021 The British Infection Association. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Letter to the Editor
Winchester, Stephen
John, Sarah
Jabbar, Kashif
John, Isaac
Clinical efficacy of nitric oxide nasal spray (NONS) for the treatment of mild COVID-19 infection
title Clinical efficacy of nitric oxide nasal spray (NONS) for the treatment of mild COVID-19 infection
title_full Clinical efficacy of nitric oxide nasal spray (NONS) for the treatment of mild COVID-19 infection
title_fullStr Clinical efficacy of nitric oxide nasal spray (NONS) for the treatment of mild COVID-19 infection
title_full_unstemmed Clinical efficacy of nitric oxide nasal spray (NONS) for the treatment of mild COVID-19 infection
title_short Clinical efficacy of nitric oxide nasal spray (NONS) for the treatment of mild COVID-19 infection
title_sort clinical efficacy of nitric oxide nasal spray (nons) for the treatment of mild covid-19 infection
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117664/
https://www.ncbi.nlm.nih.gov/pubmed/33992687
http://dx.doi.org/10.1016/j.jinf.2021.05.009
work_keys_str_mv AT winchesterstephen clinicalefficacyofnitricoxidenasalspraynonsforthetreatmentofmildcovid19infection
AT johnsarah clinicalefficacyofnitricoxidenasalspraynonsforthetreatmentofmildcovid19infection
AT jabbarkashif clinicalefficacyofnitricoxidenasalspraynonsforthetreatmentofmildcovid19infection
AT johnisaac clinicalefficacyofnitricoxidenasalspraynonsforthetreatmentofmildcovid19infection

Ejemplares similares