A Phase 2, Double-Blind, Randomized, Dose-Ranging Trial Of Reldesemtiv In Patients With ALS

OBJECTIVE: To evaluate safety, dose response, and preliminary efficacy of reldesemtiv over 12 weeks in patients with amyotrophic lateral sclerosis (ALS). METHODS: Patients (≤2 years since diagnosis) with slow upright vital capacity (SVC) of ≥60% were randomized 1:1:1:1 to reldesemtiv 150, 300, or 45...

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Autores principales: SHEFNER, JEREMY M., ANDREWS, JINSY A., GENGE, ANGELA, JACKSON, CARLAYNE, LECHTZIN, NOAH, MILLER, TIMOTHY M., COCKROFT, BETTINA M., MENG, LISA, WEI, JENNY, WOLFF, ANDREW A., MALIK, FADY I., BODKIN, CYNTHIA, BROOKS, BENJAMIN R., CARESS, JAMES, DIONNE, ANNIE, FEE, DOMINIC, GOUTMAN, STEPHEN A., GOYAL, NAMITA A., HARDIMAN, ORLA, HAYAT, GHAZALA, HEIMAN-PATTERSON, TERRY, HEITZMAN, DARAGH, HENDERSON, ROBERT D., JOHNSTON, WENDY, KARAM, CHAFIC, KIERNAN, MATTHEW C., KOLB, STEPHEN J., KORNGUT, LAWRENCE, LADHA, SHAFEEQ, MATTE, GENEVIEVE, MORA, JESUS S., NEEDHAM, MERRILEE, OSKARSSON, BJORN, PATTEE, GARY L., PIORO, ERIK P., PULLEY, MICHAEL, QUAN, DIANNA, REZANIA, KOUROSH, SCHELLENBERG, KERRI L., SCHULTZ, DAVID, SHOESMITH, CHRISTEN, SIMMONS, ZACHARY, STATLAND, JEFFREY, SULTAN, SHUMAILA, SWENSON, ANDREA, VAN DEN BERG, LEONARD H., VU, TUAN, VUCIC, STEVE, WEISS, MICHAEL, WHYTE-RAYSON, ASHLEY, WYMER, JAMES, ZINMAN, LORNE, RUDNICKI, STACY A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117790/
https://www.ncbi.nlm.nih.gov/pubmed/32969758
http://dx.doi.org/10.1080/21678421.2020.1822410

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