Cargando…

DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells

BACKGROUND: Conventional type 1 dendritic cells (cDC1s) are central to antitumor immunity and their presence in the tumor microenvironment associates with improved outcomes in patients with cancer. DNGR-1 (CLEC9A) is a dead cell-sensing receptor highly restricted to cDC1s. DNGR-1 has been involved i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cueto, Francisco J, del Fresno, Carlos, Brandi, Paola, Combes, Alexis J., Hernández-García, Elena, Sánchez-Paulete, Alfonso R, Enamorado, Michel, Bromley, Christian P, Gomez, Manuel J, Conde-Garrosa, Ruth, Mañes, Santos, Zelenay, Santiago, Melero, Ignacio, Iborra, Salvador, Krummel, Matthew F., Sancho, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118081/ https://www.ncbi.nlm.nih.gov/pubmed/33980589 http://dx.doi.org/10.1136/jitc-2020-002054

Ejemplares similares

DNGR-1, a Dendritic Cell-Specific Sensor of Tissue Damage That Dually Modulates Immunity and Inflammation
por: Cueto, Francisco J., et al.
Publicado: (2020)

Efficient and versatile manipulation of the peripheral CD4(+) T-cell compartment by antigen targeting to DNGR-1/CLEC9A
por: Joffre, Olivier P, et al.
Publicado: (2010)

SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy
por: Pan, Dong, et al.
Publicado: (2022)

Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity
por: Giampazolias, Evangelos, et al.
Publicado: (2021)

Tumorous expression of NAC1 restrains antitumor immunity through the LDHA-mediated immune evasion
por: Ren, Yijie, et al.
Publicado: (2022)

Characterization of human DNGR-1(+) BDCA3(+) leukocytes as putative equivalents of mouse CD8α(+) dendritic cells
por: Poulin, Lionel Franz, et al.
Publicado: (2010)

The Flt3L/Flt3 Axis in Dendritic Cell Biology and Cancer Immunotherapy
por: Cueto, Francisco J., et al.
Publicado: (2021)

Batf3-dependent CD103(+) dendritic cells are major producers of IL-12 that drive local Th1 immunity against Leishmania major infection in mice
por: Martínez-López, María, et al.
Publicado: (2015)

Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8(+) T cells
por: Enamorado, Michel, et al.
Publicado: (2017)

Nicotinamide combined with gemcitabine is an immunomodulatory therapy that restrains pancreatic cancer in mice
por: Selvanesan, Benson Chellakkan, et al.
Publicado: (2020)

Oncogenic Transformation of Dendritic Cells and Their Precursors Leads to Rapid Cancer Development in Mice
por: Böttcher, Jan P., et al.
Publicado: (2015)

Genealogy, Dendritic Cell Priming, and Differentiation of Tissue-Resident Memory CD8(+) T Cells
por: Enamorado, Michel, et al.
Publicado: (2018)

DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential
por: Frederico, Bruno, et al.
Publicado: (2022)

Cellular cytotoxicity is a form of immunogenic cell death
por: Minute, Luna, et al.
Publicado: (2020)

Targeting DNGR-1 (CLEC9A) with antibody/MUC1 peptide conjugates as a vaccine for carcinomas
por: Picco, Gianfranco, et al.
Publicado: (2014)

Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen
por: Wculek, Stefanie K., et al.
Publicado: (2019)

Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8(+) T cells
por: Dwyer, Connor J., et al.
Publicado: (2020)

Von Hippel-Lindau Protein Is Required for Optimal Alveolar Macrophage Terminal Differentiation, Self-Renewal, and Function
por: Izquierdo, Helena M., et al.
Publicado: (2018)

Inhibition of tumor‐associated macrophages by trabectedin improves the antitumor adaptive immunity in response to anti‐PD‐1 therapy
por: Belgiovine, Cristina, et al.
Publicado: (2021)

Myosin II Synergizes with F-Actin to Promote DNGR-1-Dependent Cross-Presentation of Dead Cell-Associated Antigens
por: Schulz, Oliver, et al.
Publicado: (2018)

ACKR4 restrains antitumor immunity by regulating CCL21
por: Whyte, Carly E., et al.
Publicado: (2020)

Conventional type 1 dendritic cells protect against age-related adipose tissue dysfunction and obesity
por: Hernández-García, Elena, et al.
Publicado: (2022)

IL-31 induces antitumor immunity in breast carcinoma
por: Kan, Tal, et al.
Publicado: (2020)

A pH‐ and ionic strength‐dependent conformational change in the neck region regulates DNGR‐1 function in dendritic cells
por: Hanč, Pavel, et al.
Publicado: (2016)

SUN-LB056 The Pharmacological Blockade of the Splicing Factor SF3B1 Exerts Antitumor Actions in Different Endocrine-Related Cancers
por: Gahete, Manuel, et al.
Publicado: (2019)

Giant Cell Tumor (GCT) of Capitate
por: Narayana Gowda, BS, et al.
Publicado: (2012)

A Proposal for Nomenclature in Myeloid C-Type Lectin Receptors
por: del Fresno, Carlos, et al.
Publicado: (2019)

Improved prognosis in soft-tissue sarcoma of extremity and trunk wall: Comparison of patients diagnosed during 1998–2001 and 2005–2010 in Finland
por: Sampo, Mika M, et al.
Publicado: (2017)

Dual receptor T cells mediate effective antitumor immune responses via increased recognition of tumor antigens
por: Jang, Hyun J, et al.
Publicado: (2023)

Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity
por: Efimova, Iuliia, et al.
Publicado: (2020)

CXCR6 is required for antitumor efficacy of intratumoral CD8(+) T cell
por: Wang, Binglin, et al.
Publicado: (2021)

Left Subclavian Artery Pseudoaneurysm after a Traffic Accident: A Case Report
por: Enamorado-Enamorado, J., et al.
Publicado: (2011)

Vaccination with post-translational modified, homocitrullinated peptides induces CD8 T-cell responses that mediate antitumor immunity
por: Shah, Sabaria, et al.
Publicado: (2023)

Overcoming resistance to STING agonist therapy to incite durable protective antitumor immunity
por: Lemos, Henrique, et al.
Publicado: (2020)

Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor
por: You, Dan, et al.
Publicado: (2021)

Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity
por: Wang, Zining, et al.
Publicado: (2021)

Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy
por: Liu, Xia, et al.
Publicado: (2022)

Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity
por: Kalim, Khalid W, et al.
Publicado: (2022)

BRCA1 deficiency in mature CD8(+) T lymphocytes impairs antitumor immunity
por: Wu, Bogang, et al.
Publicado: (2023)

Concomitant or delayed anti-TNF differentially impact on immune-related adverse events and antitumor efficacy after anti-CD40 therapy
por: Jacoberger-Foissac, Celia, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_jiho2lcdu7iqkjab6ia9tkv5dm