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Increased Prevalence of Minor Physical Anomalies Among the Healthy First-Degree Relatives of Bipolar I Patients – Results With the Méhes Scale

Minor physical anomalies are somatic markers of aberrant neurodevelopment, so the higher prevalence of these signs among the relatives of bipolar I patients can confirm minor physical anomalies as endophenotypes. The aim of the study was to evaluate the prevalence of minor physical anomalies in firs...

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Autores principales: Csulak, Tímea, Csábi, Györgyi, Herold, Róbert, Vörös, Viktor, Jeges, Sára, Hajnal, András, Kovács, Márton Áron, Simon, Maria, Herold, Márton, Tóth, Ákos Levente, Tényi, Tamás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118159/
https://www.ncbi.nlm.nih.gov/pubmed/33995153
http://dx.doi.org/10.3389/fpsyt.2021.672241
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author Csulak, Tímea
Csábi, Györgyi
Herold, Róbert
Vörös, Viktor
Jeges, Sára
Hajnal, András
Kovács, Márton Áron
Simon, Maria
Herold, Márton
Tóth, Ákos Levente
Tényi, Tamás
author_facet Csulak, Tímea
Csábi, Györgyi
Herold, Róbert
Vörös, Viktor
Jeges, Sára
Hajnal, András
Kovács, Márton Áron
Simon, Maria
Herold, Márton
Tóth, Ákos Levente
Tényi, Tamás
author_sort Csulak, Tímea
collection PubMed
description Minor physical anomalies are somatic markers of aberrant neurodevelopment, so the higher prevalence of these signs among the relatives of bipolar I patients can confirm minor physical anomalies as endophenotypes. The aim of the study was to evaluate the prevalence of minor physical anomalies in first-degree healthy relatives of patients with bipolar I disorder compared to normal control subjects. Using a list of 57 minor physical anomalies (the Méhes Scale), 20 first-degree unaffected relatives of patients with the diagnosis of bipolar I disorder and as a comparison 20 matched normal control subjects were examined. Minor physical anomalies were more common in the ear, head, mouth and trunk regions among the relatives of bipolar I patients compared to normal controls. By the differentiation of minor malformations and phenogenetic variants, we have found that both minor malformations and phenogenetic variants were more common among the relatives of bipolar I patients compared to the control group, while individual analyses showed, that one minor malformation (sole crease) and one phenogenetic variant (high arched palate) were more prevalent in the relative group. This is the first report in literature on the increased prevalence of minor physical anomalies among the first-degree unaffected relatives of bipolar I patients. The study support the concept, that minor physical anomalies can be endophenotypic markers of bipolar I affective disorder.
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spelling pubmed-81181592021-05-14 Increased Prevalence of Minor Physical Anomalies Among the Healthy First-Degree Relatives of Bipolar I Patients – Results With the Méhes Scale Csulak, Tímea Csábi, Györgyi Herold, Róbert Vörös, Viktor Jeges, Sára Hajnal, András Kovács, Márton Áron Simon, Maria Herold, Márton Tóth, Ákos Levente Tényi, Tamás Front Psychiatry Psychiatry Minor physical anomalies are somatic markers of aberrant neurodevelopment, so the higher prevalence of these signs among the relatives of bipolar I patients can confirm minor physical anomalies as endophenotypes. The aim of the study was to evaluate the prevalence of minor physical anomalies in first-degree healthy relatives of patients with bipolar I disorder compared to normal control subjects. Using a list of 57 minor physical anomalies (the Méhes Scale), 20 first-degree unaffected relatives of patients with the diagnosis of bipolar I disorder and as a comparison 20 matched normal control subjects were examined. Minor physical anomalies were more common in the ear, head, mouth and trunk regions among the relatives of bipolar I patients compared to normal controls. By the differentiation of minor malformations and phenogenetic variants, we have found that both minor malformations and phenogenetic variants were more common among the relatives of bipolar I patients compared to the control group, while individual analyses showed, that one minor malformation (sole crease) and one phenogenetic variant (high arched palate) were more prevalent in the relative group. This is the first report in literature on the increased prevalence of minor physical anomalies among the first-degree unaffected relatives of bipolar I patients. The study support the concept, that minor physical anomalies can be endophenotypic markers of bipolar I affective disorder. Frontiers Media S.A. 2021-04-29 /pmc/articles/PMC8118159/ /pubmed/33995153 http://dx.doi.org/10.3389/fpsyt.2021.672241 Text en Copyright © 2021 Csulak, Csábi, Herold, Vörös, Jeges, Hajnal, Kovács, Simon, Herold, Tóth and Tényi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Csulak, Tímea
Csábi, Györgyi
Herold, Róbert
Vörös, Viktor
Jeges, Sára
Hajnal, András
Kovács, Márton Áron
Simon, Maria
Herold, Márton
Tóth, Ákos Levente
Tényi, Tamás
Increased Prevalence of Minor Physical Anomalies Among the Healthy First-Degree Relatives of Bipolar I Patients – Results With the Méhes Scale
title Increased Prevalence of Minor Physical Anomalies Among the Healthy First-Degree Relatives of Bipolar I Patients – Results With the Méhes Scale
title_full Increased Prevalence of Minor Physical Anomalies Among the Healthy First-Degree Relatives of Bipolar I Patients – Results With the Méhes Scale
title_fullStr Increased Prevalence of Minor Physical Anomalies Among the Healthy First-Degree Relatives of Bipolar I Patients – Results With the Méhes Scale
title_full_unstemmed Increased Prevalence of Minor Physical Anomalies Among the Healthy First-Degree Relatives of Bipolar I Patients – Results With the Méhes Scale
title_short Increased Prevalence of Minor Physical Anomalies Among the Healthy First-Degree Relatives of Bipolar I Patients – Results With the Méhes Scale
title_sort increased prevalence of minor physical anomalies among the healthy first-degree relatives of bipolar i patients – results with the méhes scale
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118159/
https://www.ncbi.nlm.nih.gov/pubmed/33995153
http://dx.doi.org/10.3389/fpsyt.2021.672241
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