Microglial Gi-dependent dynamics regulate brain network hyperexcitability

Microglial surveillance is a key feature of brain physiology and disease. We found that Gi-dependent microglial dynamics prevent neuronal network hyperexcitability. By generating Mg(PTX) mice to genetically inhibit Gi in microglia, we showed that sustained reduction of microglia brain surveillance a...

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Detalles Bibliográficos
Autores principales: Merlini, Mario, Rafalski, Victoria A., Ma, Keran, Kim, Keun-Young, Bushong, Eric A., Rios Coronado, Pamela E., Yan, Zhaoqi, Mendiola, Andrew S., Sozmen, Elif G., Ryu, Jae Kyu, Haberl, Matthias G., Madany, Matthew, Sampson, Daniel Naranjo, Petersen, Mark A., Bardehle, Sophia, Tognatta, Reshmi, Dean, Terry, Acevedo, Rosa Meza, Cabriga, Belinda, Thomas, Reuben, Coughlin, Shaun R., Ellisman, Mark H., Palop, Jorge J., Akassoglou, Katerina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118167/
https://www.ncbi.nlm.nih.gov/pubmed/33318667
http://dx.doi.org/10.1038/s41593-020-00756-7
Descripción
Sumario:Microglial surveillance is a key feature of brain physiology and disease. We found that Gi-dependent microglial dynamics prevent neuronal network hyperexcitability. By generating Mg(PTX) mice to genetically inhibit Gi in microglia, we showed that sustained reduction of microglia brain surveillance and directed process motility induced spontaneous seizures and increased hypersynchrony upon physiologically evoked neuronal activity in awake adult mice. Thus, Gi-dependent microglia dynamics may prevent hyperexcitability in neurological diseases.

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