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Microglial Gi-dependent dynamics regulate brain network hyperexcitability
Microglial surveillance is a key feature of brain physiology and disease. We found that Gi-dependent microglial dynamics prevent neuronal network hyperexcitability. By generating Mg(PTX) mice to genetically inhibit Gi in microglia, we showed that sustained reduction of microglia brain surveillance a...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118167/ https://www.ncbi.nlm.nih.gov/pubmed/33318667 http://dx.doi.org/10.1038/s41593-020-00756-7 |
| _version_ | 1783691699359318016 |
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| author | Merlini, Mario Rafalski, Victoria A. Ma, Keran Kim, Keun-Young Bushong, Eric A. Rios Coronado, Pamela E. Yan, Zhaoqi Mendiola, Andrew S. Sozmen, Elif G. Ryu, Jae Kyu Haberl, Matthias G. Madany, Matthew Sampson, Daniel Naranjo Petersen, Mark A. Bardehle, Sophia Tognatta, Reshmi Dean, Terry Acevedo, Rosa Meza Cabriga, Belinda Thomas, Reuben Coughlin, Shaun R. Ellisman, Mark H. Palop, Jorge J. Akassoglou, Katerina |
| author_facet | Merlini, Mario Rafalski, Victoria A. Ma, Keran Kim, Keun-Young Bushong, Eric A. Rios Coronado, Pamela E. Yan, Zhaoqi Mendiola, Andrew S. Sozmen, Elif G. Ryu, Jae Kyu Haberl, Matthias G. Madany, Matthew Sampson, Daniel Naranjo Petersen, Mark A. Bardehle, Sophia Tognatta, Reshmi Dean, Terry Acevedo, Rosa Meza Cabriga, Belinda Thomas, Reuben Coughlin, Shaun R. Ellisman, Mark H. Palop, Jorge J. Akassoglou, Katerina |
| author_sort | Merlini, Mario |
| collection | PubMed |
| description | Microglial surveillance is a key feature of brain physiology and disease. We found that Gi-dependent microglial dynamics prevent neuronal network hyperexcitability. By generating Mg(PTX) mice to genetically inhibit Gi in microglia, we showed that sustained reduction of microglia brain surveillance and directed process motility induced spontaneous seizures and increased hypersynchrony upon physiologically evoked neuronal activity in awake adult mice. Thus, Gi-dependent microglia dynamics may prevent hyperexcitability in neurological diseases. |
| format | Online Article Text |
| id | pubmed-8118167 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-81181672021-06-14 Microglial Gi-dependent dynamics regulate brain network hyperexcitability Merlini, Mario Rafalski, Victoria A. Ma, Keran Kim, Keun-Young Bushong, Eric A. Rios Coronado, Pamela E. Yan, Zhaoqi Mendiola, Andrew S. Sozmen, Elif G. Ryu, Jae Kyu Haberl, Matthias G. Madany, Matthew Sampson, Daniel Naranjo Petersen, Mark A. Bardehle, Sophia Tognatta, Reshmi Dean, Terry Acevedo, Rosa Meza Cabriga, Belinda Thomas, Reuben Coughlin, Shaun R. Ellisman, Mark H. Palop, Jorge J. Akassoglou, Katerina Nat Neurosci Article Microglial surveillance is a key feature of brain physiology and disease. We found that Gi-dependent microglial dynamics prevent neuronal network hyperexcitability. By generating Mg(PTX) mice to genetically inhibit Gi in microglia, we showed that sustained reduction of microglia brain surveillance and directed process motility induced spontaneous seizures and increased hypersynchrony upon physiologically evoked neuronal activity in awake adult mice. Thus, Gi-dependent microglia dynamics may prevent hyperexcitability in neurological diseases. 2020-12-14 2021-01 /pmc/articles/PMC8118167/ /pubmed/33318667 http://dx.doi.org/10.1038/s41593-020-00756-7 Text en http://www.nature.com/authors/editorial_policies/license.html#termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Merlini, Mario Rafalski, Victoria A. Ma, Keran Kim, Keun-Young Bushong, Eric A. Rios Coronado, Pamela E. Yan, Zhaoqi Mendiola, Andrew S. Sozmen, Elif G. Ryu, Jae Kyu Haberl, Matthias G. Madany, Matthew Sampson, Daniel Naranjo Petersen, Mark A. Bardehle, Sophia Tognatta, Reshmi Dean, Terry Acevedo, Rosa Meza Cabriga, Belinda Thomas, Reuben Coughlin, Shaun R. Ellisman, Mark H. Palop, Jorge J. Akassoglou, Katerina Microglial Gi-dependent dynamics regulate brain network hyperexcitability |
| title | Microglial Gi-dependent dynamics regulate brain network hyperexcitability |
| title_full | Microglial Gi-dependent dynamics regulate brain network hyperexcitability |
| title_fullStr | Microglial Gi-dependent dynamics regulate brain network hyperexcitability |
| title_full_unstemmed | Microglial Gi-dependent dynamics regulate brain network hyperexcitability |
| title_short | Microglial Gi-dependent dynamics regulate brain network hyperexcitability |
| title_sort | microglial gi-dependent dynamics regulate brain network hyperexcitability |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118167/ https://www.ncbi.nlm.nih.gov/pubmed/33318667 http://dx.doi.org/10.1038/s41593-020-00756-7 |
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