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Does blood type affect the COVID-19 infection pattern?

Among the many aspects that characterize the COVID-19 pandemic, two seem particularly challenging to understand: i) the great geographical differences in the degree of virus contagiousness and lethality that were found in the different phases of the epidemic progression, and, ii) the potential role...

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Autores principales: Miotto, Mattia, Di Rienzo, Lorenzo, Gosti, Giorgio, Milanetti, Edoardo, Ruocco, Giancarlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118288/
https://www.ncbi.nlm.nih.gov/pubmed/33984040
http://dx.doi.org/10.1371/journal.pone.0251535
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author Miotto, Mattia
Di Rienzo, Lorenzo
Gosti, Giorgio
Milanetti, Edoardo
Ruocco, Giancarlo
author_facet Miotto, Mattia
Di Rienzo, Lorenzo
Gosti, Giorgio
Milanetti, Edoardo
Ruocco, Giancarlo
author_sort Miotto, Mattia
collection PubMed
description Among the many aspects that characterize the COVID-19 pandemic, two seem particularly challenging to understand: i) the great geographical differences in the degree of virus contagiousness and lethality that were found in the different phases of the epidemic progression, and, ii) the potential role of the infected people’s blood type in both the virus infectivity and the progression of the disease. A recent hypothesis could shed some light on both aspects. Specifically, it has been proposed that, in the subject-to-subject transfer, SARS-CoV-2 conserves on its capsid the erythrocytes’ antigens of the source subject. Thus these conserved antigens can potentially cause an immune reaction in a receiving subject that has previously acquired specific antibodies for the source subject antigens. This hypothesis implies a blood type-dependent infection rate. The strong geographical dependence of the blood type distribution could be, therefore, one of the factors at the origin of the observed heterogeneity in the epidemics spread. Here, we present an epidemiological deterministic model where the infection rules based on blood types are taken into account, and we compare our model outcomes with the exiting worldwide infection progression data. We found an overall good agreement, which strengthens the hypothesis that blood types do play a role in the COVID-19 infection.
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spelling pubmed-81182882021-05-24 Does blood type affect the COVID-19 infection pattern? Miotto, Mattia Di Rienzo, Lorenzo Gosti, Giorgio Milanetti, Edoardo Ruocco, Giancarlo PLoS One Research Article Among the many aspects that characterize the COVID-19 pandemic, two seem particularly challenging to understand: i) the great geographical differences in the degree of virus contagiousness and lethality that were found in the different phases of the epidemic progression, and, ii) the potential role of the infected people’s blood type in both the virus infectivity and the progression of the disease. A recent hypothesis could shed some light on both aspects. Specifically, it has been proposed that, in the subject-to-subject transfer, SARS-CoV-2 conserves on its capsid the erythrocytes’ antigens of the source subject. Thus these conserved antigens can potentially cause an immune reaction in a receiving subject that has previously acquired specific antibodies for the source subject antigens. This hypothesis implies a blood type-dependent infection rate. The strong geographical dependence of the blood type distribution could be, therefore, one of the factors at the origin of the observed heterogeneity in the epidemics spread. Here, we present an epidemiological deterministic model where the infection rules based on blood types are taken into account, and we compare our model outcomes with the exiting worldwide infection progression data. We found an overall good agreement, which strengthens the hypothesis that blood types do play a role in the COVID-19 infection. Public Library of Science 2021-05-13 /pmc/articles/PMC8118288/ /pubmed/33984040 http://dx.doi.org/10.1371/journal.pone.0251535 Text en © 2021 Miotto et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Miotto, Mattia
Di Rienzo, Lorenzo
Gosti, Giorgio
Milanetti, Edoardo
Ruocco, Giancarlo
Does blood type affect the COVID-19 infection pattern?
title Does blood type affect the COVID-19 infection pattern?
title_full Does blood type affect the COVID-19 infection pattern?
title_fullStr Does blood type affect the COVID-19 infection pattern?
title_full_unstemmed Does blood type affect the COVID-19 infection pattern?
title_short Does blood type affect the COVID-19 infection pattern?
title_sort does blood type affect the covid-19 infection pattern?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118288/
https://www.ncbi.nlm.nih.gov/pubmed/33984040
http://dx.doi.org/10.1371/journal.pone.0251535
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