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To “Z” or not to “Z”: Z-RNA, self-recognition, and the MDA5 helicase
Double-stranded RNA (dsRNA) is produced both by virus and host. Its recognition by the melanoma differentiation–associated gene 5 (MDA5) initiates type I interferon responses. How can a host distinguish self-transcripts from nonself to ensure that responses are targeted correctly? Here, I discuss a...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118290/ https://www.ncbi.nlm.nih.gov/pubmed/33983939 http://dx.doi.org/10.1371/journal.pgen.1009513 |