RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain

Adenosine deaminase acting on RNA 1 (ADAR1), an enzyme responsible for adenosine-to-inosine RNA editing, is composed of two isoforms: nuclear p110 and cytoplasmic p150. Deletion of Adar1 or Adar1 p150 genes in mice results in embryonic lethality with overexpression of interferon-stimulating genes (I...

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Detalles Bibliográficos
Autores principales: Kim, Jung In, Nakahama, Taisuke, Yamasaki, Ryuichiro, Costa Cruz, Pedro Henrique, Vongpipatana, Tuangtong, Inoue, Maal, Kanou, Nao, Xing, Yanfang, Todo, Hiroyuki, Shibuya, Toshiharu, Kato, Yuki, Kawahara, Yukio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118328/
https://www.ncbi.nlm.nih.gov/pubmed/33983932
http://dx.doi.org/10.1371/journal.pgen.1009516

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