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Multi-omics approach identifies germline regulatory variants associated with hematopoietic malignancies in retriever dog breeds

Histiocytic sarcoma is an aggressive hematopoietic malignancy of mature tissue histiocytes with a poorly understood etiology in humans. A histologically and clinically similar counterpart affects flat-coated retrievers (FCRs) at unusually high frequency, with 20% developing the lethal disease. The s...

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Detalles Bibliográficos
Autores principales:	Evans, Jacquelyn M., Parker, Heidi G., Rutteman, Gerard R., Plassais, Jocelyn, Grinwis, Guy C. M., Harris, Alexander C., Lana, Susan E., Ostrander, Elaine A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118335/ https://www.ncbi.nlm.nih.gov/pubmed/33983928 http://dx.doi.org/10.1371/journal.pgen.1009543

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