Design and synthesis of pyrazolone-based compounds as potent blockers of SARS-CoV-2 viral entry into the host cells

SARS-CoV-2 are enveloped positive-stranded RNA viruses that replicate in the cytoplasm. It relies on the fusion of their envelope with the host cell membrane to deliver their nucleocapsid into the host cell. The spike glycoprotein (S) mediates virus entry into cells via the human Angiotensin-convert...

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Detalles Bibliográficos
Autores principales: Obakachi, Vincent A., Kushwaha, Narva Deshwar, Kushwaha, Babita, Mahlalela, Mavela Cleopus, Shinde, Suraj Raosaheb, Kehinde, Idowu, Karpoormath, Rajshekhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118388/
https://www.ncbi.nlm.nih.gov/pubmed/34007088
http://dx.doi.org/10.1016/j.molstruc.2021.130665

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