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What role for AHR activation in IL4I1-mediated immunosuppression ?

The amino-acid catabolizing enzyme Interleukin-4 induced gene 1 (IL4I1) remains poorly characterized despite it is emerging as a pertinent therapeutic target for cancer. IL4I1 is secreted in the synaptic cleft by antigen-presenting cells. It inhibits TCR signaling, modulates naïve T cell differentia...

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Detalles Bibliográficos
Autores principales:	Castellano, Flavia, Prevost-Blondel, Armelle, Cohen, José L., Molinier-Frenkel, Valérie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118450/ https://www.ncbi.nlm.nih.gov/pubmed/34026337 http://dx.doi.org/10.1080/2162402X.2021.1924500

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