Cargando…

Senataxin: A New Guardian of the Female Germline Important for Delaying Ovarian Aging

Early decline in ovarian function known as premature ovarian aging (POA) occurs in around 10% of women and is characterized by a markedly reduced ovarian reserve. Premature ovarian insufficiency (POI) affects ~1% of women and refers to the severe end of the POA spectrum in which, accelerated ovarian...

Descripción completa

Detalles Bibliográficos
Autor principal:	Homer, Hayden A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118517/ https://www.ncbi.nlm.nih.gov/pubmed/33995483 http://dx.doi.org/10.3389/fgene.2021.647996

Ejemplares similares

Germline Copy Number Variation and Ovarian Cancer Survival
por: Fridley, Brooke L., et al.
Publicado: (2012)

Prmt5: a guardian of the germline protects future generations
por: Berrens, Rebecca V, et al.
Publicado: (2015)

Regulating autophagy: a novel role for SETX (Senataxin)
por: Richard, Patricia, et al.
Publicado: (2021)

Senataxin protects the genome: Implications for neurodegeneration and other abnormalities
por: Lavin, Martin F., et al.
Publicado: (2013)

Senataxin and R-loops homeostasis: multifaced implications in carcinogenesis
por: Gatti, Veronica, et al.
Publicado: (2023)

Editorial: Female Infertility: Genetics of Reproductive Ageing, Menopause and Primary Ovarian Insufficiency
por: Marongiu, Mara, et al.
Publicado: (2022)

USP11 controls R-loops by regulating senataxin proteostasis
por: Jurga, Mateusz, et al.
Publicado: (2021)

Effects of senataxin and RNA exosome on B-cell chromosomal integrity
por: Kazadi, David, et al.
Publicado: (2020)

Germline-Restricted Chromosome (GRC) in Female and Male Meiosis of the Great Tit (Parus major, Linnaeus, 1758)
por: Torgasheva, Anna, et al.
Publicado: (2021)

Clinical and Molecular Aspects of Senataxin Mutations in Amyotrophic Lateral Sclerosis 4
por: Grunseich, Christopher, et al.
Publicado: (2020)

The helicase senataxin suppresses the antiviral transcriptional response and controls viral biogenesis
por: Miller, Matthew S., et al.
Publicado: (2015)

Senataxin controls meiotic silencing through ATR activation and chromatin remodeling
por: Yeo, Abrey J, et al.
Publicado: (2015)

Hereditary Ataxia with a Novel Mutation in the Senataxin Gene: A Case Report
por: Moghanloo, Ehsan, et al.
Publicado: (2019)

Next-generation sequencing of BRCA1 and BRCA2 genes for rapid detection of germline mutations in hereditary breast/ovarian cancer
por: Nicolussi, Arianna, et al.
Publicado: (2019)

New Pathogenic Germline Variants in Very Early Onset and Familial Colorectal Cancer Patients
por: Djursby, Malene, et al.
Publicado: (2020)

Human Germline Interventions–Think First
por: Hildt, Elisabeth
Publicado: (2016)

Ethical Challenges of Germline Genetic Enhancement
por: Macpherson, Ignacio, et al.
Publicado: (2019)

Prevalence of Clinically Relevant Germline BRCA Variants in a Large Unselected South African Breast and Ovarian Cancer Cohort: A Public Sector Experience
por: Van der Merwe, Nerina C., et al.
Publicado: (2022)

The guardian
por: ATLAS Collaboration
Publicado: (2015)

BRCA1 and BRCA2 germline mutation spectrum and frequencies in Belgian breast/ovarian cancer families
por: Claes, K, et al.
Publicado: (2004)

Protein Interaction Analysis of Senataxin and the ALS4 L389S Mutant Yields Insights into Senataxin Post-Translational Modification and Uncovers Mutant-Specific Binding with a Brain Cytoplasmic RNA-Encoded Peptide
por: Bennett, Craig L., et al.
Publicado: (2013)

Aberrant Splicing of the Senataxin Gene in a Patient with Ataxia with Oculomotor Apraxia Type 2
por: Fogel, Brent L., et al.
Publicado: (2009)

Germline Structural Variations in Cancer Predisposition Genes
por: Pócza, Tímea, et al.
Publicado: (2021)

Combined germline and tumor mutation signature testing identifies new families with NTHL1 tumor syndrome
por: Pinto, Carla, et al.
Publicado: (2023)

Measurement delay associated with the Guardian® RT continuous glucose monitoring system
por: Wei, C, et al.
Publicado: (2010)

Nucleophagy delays aging and preserves germline immortality
por: Papandreou, Margarita-Elena, et al.
Publicado: (2022)

Mutation in senataxin alters the mechanism of R-loop resolution in amyotrophic lateral sclerosis 4
por: Kannan, Annapoorna, et al.
Publicado: (2022)

MAIT cells: new guardians of the liver
por: Kurioka, Ayako, et al.
Publicado: (2016)

MAIT cells: new guardians of the liver
por: Kurioka, Ayako, et al.
Publicado: (2017)

Is DNA methylation the new guardian of the genome?
por: Hoffman, Robert M.
Publicado: (2017)

Germline (epi)genetics reveals high predisposition in females: a 5-year, nationwide, prospective Wilms tumour cohort
por: Stoltze, Ulrik Kristoffer, et al.
Publicado: (2023)

Identification of Key Genes and Potential New Biomarkers for Ovarian Aging: A Study Based on RNA-Sequencing Data
por: Ma, Lingwei, et al.
Publicado: (2020)

Germline Risk Contribution to Genomic Instability in Multiple Myeloma
por: Janz, Siegfried, et al.
Publicado: (2019)

A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links
por: Andrews, Alex M., et al.
Publicado: (2018)

Human senataxin is a bona fide R-loop resolving enzyme and transcription termination factor
por: Hasanova, Zdenka, et al.
Publicado: (2023)

Female germline stem cells: aging and anti-aging
por: Hong, Wenli, et al.
Publicado: (2022)

New germline mutations in the hypervariable minisatellite CEB1 in the parents of children with leukaemia
por: Davies, B G, et al.
Publicado: (2007)

Diablo guardián /
por: Velasco, Xavier
Publicado: (2004)

Diablo guardián /
por: Velasco, Xavier
Publicado: (2006)

Diablo guardián
por: Velasco, Xavier
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_qqtn196agedg6p4d3bp1abd5kf