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The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr

Silencing of nuclear DNA is an essential feature of innate immune responses to invading pathogens. Early in infection, unintegrated lentiviral cDNA accumulates in the nucleus yet remains poorly expressed. In HIV-1-like lentiviruses, the Vpr accessory protein enhances unintegrated viral DNA expressio...

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Detalles Bibliográficos
Autores principales:	Dupont, Liane, Bloor, Stuart, Williamson, James C., Cuesta, Sergio Martínez, Shah, Raven, Teixeira-Silva, Ana, Naamati, Adi, Greenwood, Edward J.D., Sarafianos, Stefan G., Matheson, Nicholas J., Lehner, Paul J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118623/ https://www.ncbi.nlm.nih.gov/pubmed/33811831 http://dx.doi.org/10.1016/j.chom.2021.03.001

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