Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2

To understand the spread of SARS-CoV2, in August and September 2020, the Council of Scientific and Industrial Research (India) conducted a serosurvey across its constituent laboratories and centers across India. Of 10,427 volunteers, 1058 (10.14%) tested positive for SARS-CoV2 anti-nucleocapsid (ant...

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Autores principales: Naushin, Salwa, Sardana, Viren, Ujjainiya, Rajat, Bhatheja, Nitin, Kutum, Rintu, Bhaskar, Akash Kumar, Pradhan, Shalini, Prakash, Satyartha, Khan, Raju, Rawat, Birendra Singh, Tallapaka, Karthik Bharadwaj, Anumalla, Mahesh, Chandak, Giriraj Ratan, Lahiri, Amit, Kar, Susanta, Mulay, Shrikant Ramesh, Mugale, Madhav Nilakanth, Srivastava, Mrigank, Khan, Shaziya, Srivastava, Anjali, Tomar, Bhawana, Veerapandian, Murugan, Venkatachalam, Ganesh, Vijayakumar, Selvamani Raja, Agarwal, Ajay, Gupta, Dinesh, Halami, Prakash M, Peddha, Muthukumar Serva, Sundaram, Gopinath M, Veeranna, Ravindra P, Pal, Anirban, Agarwal, Vinay Kumar, Maurya, Anil Ku, Singh, Ranvijay Kumar, Raman, Ashok Kumar, Anandasadagopan, Suresh Kumar, Karuppanan, Parimala, Venkatesan, Subramanian, Sardana, Harish Kumar, Kothari, Anamika, Jain, Rishabh, Thakur, Anupama, Parihar, Devendra Singh, Saifi, Anas, Kaur, Jasleen, Kumar, Virendra, Mishra, Avinash, Gogeri, Iranna, Rayasam, Geethavani, Singh, Praveen, Chakraborty, Rahul, Chaturvedi, Gaura, Karunakar, Pinreddy, Yadav, Rohit, Singhmar, Sunanda, Singh, Dayanidhi, Sarkar, Sharmistha, Bhattacharya, Purbasha, Acharya, Sundaram, Singh, Vandana, Verma, Shweta, Soni, Drishti, Seth, Surabhi, Vashisht, Sakshi, Thakran, Sarita, Fatima, Firdaus, Singh, Akash Pratap, Sharma, Akanksha, Sharma, Babita, Subramanian, Manikandan, Padwad, Yogendra S, Hallan, Vipin, Patial, Vikram, Singh, Damanpreet, Tripude, Narendra Vijay, Chakrabarti, Partha, Maity, Sujay Krishna, Ganguly, Dipyaman, Sarkar, Jit, Ramakrishna, Sistla, Kumar, Balthu Narender, Kumar, Kiran A, Gandhi, Sumit G, Jamwal, Piyush Singh, Chouhan, Rekha, Jamwal, Vijay Lakshmi, Kapoor, Nitika, Ghosh, Debashish, Thakkar, Ghanshyam, Subudhi, Umakanta, Sen, Pradip, Chaudhury, Saumya Ray, Kumar, Rashmi, Gupta, Pawan, Tuli, Amit, Sharma, Deepak, Ringe, Rajesh P, D, Amarnarayan, Kulkarni, Mahesh, Shanmugam, Dhansekaran, Dharne, Mahesh S, Dastager, Sayed G, Joshi, Rakesh, Patil, Amita P, Mahajan, Sachin N, Khan, Abujunaid Habib, Wagh, Vasudev, Yadav, Rakesh Kumar, Khilari, Ajinkya, Bhadange, Mayuri, Chaurasiya, Arvindkumar H, Kulsange, Shabda E, Khairnar, Krishna, Paranjape, Shilpa, Kalita, Jatin, Sastry, Narahari G, Phukan, Tridip, Manna, Prasenjit, Romi, Wahengbam, Bharali, Pankaj, Ozah, Dibyajyoti, Sahu, Ravi Kumar, Babu, Elapavalooru VSSK, Sukumaran, Rajeev, Nair, Aiswarya R, Valappil, Prajeesh Kooloth, Puthiyamadam, Anoop, Velayudhanpillai, Adarsh, Chodankar, Kalpana, Damare, Samir, Madhavi, Yennapu, Aggarwal, Ved Varun, Dahiya, Sumit, Agrawal, Anurag, Dash, Debasis, Sengupta, Shantanu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118652/
https://www.ncbi.nlm.nih.gov/pubmed/33876727
http://dx.doi.org/10.7554/eLife.66537
Descripción
Sumario:To understand the spread of SARS-CoV2, in August and September 2020, the Council of Scientific and Industrial Research (India) conducted a serosurvey across its constituent laboratories and centers across India. Of 10,427 volunteers, 1058 (10.14%) tested positive for SARS-CoV2 anti-nucleocapsid (anti-NC) antibodies, 95% of which had surrogate neutralization activity. Three-fourth of these recalled no symptoms. Repeat serology tests at 3 (n = 607) and 6 (n = 175) months showed stable anti-NC antibodies but declining neutralization activity. Local seropositivity was higher in densely populated cities and was inversely correlated with a 30-day change in regional test positivity rates (TPRs). Regional seropositivity above 10% was associated with declining TPR. Personal factors associated with higher odds of seropositivity were high-exposure work (odds ratio, 95% confidence interval, p value: 2.23, 1.92–2.59, <0.0001), use of public transport (1.79, 1.43–2.24, <0.0001), not smoking (1.52, 1.16–1.99, 0.0257), non-vegetarian diet (1.67, 1.41–1.99, <0.0001), and B blood group (1.36, 1.15–1.61, 0.001).

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