The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function

Aging is accompanied by disrupted information flow, resulting from accumulation of molecular mistakes. These mistakes ultimately give rise to debilitating disorders including skeletal muscle wasting, or sarcopenia. To derive a global metric of growing ‘disorderliness’ of aging muscle, we employed a...

Descripción completa

Detalles Bibliográficos
Autores principales: Clemens, Zachary, Sivakumar, Sruthi, Pius, Abish, Sahu, Amrita, Shinde, Sunita, Mamiya, Hikaru, Luketich, Nathaniel, Cui, Jian, Dixit, Purushottam, Hoeck, Joerg D, Kreuz, Sebastian, Franti, Michael, Barchowsky, Aaron, Ambrosio, Fabrisia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118657/
https://www.ncbi.nlm.nih.gov/pubmed/33876724
http://dx.doi.org/10.7554/eLife.61138

Ejemplares similares

Ejemplares similares