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Relationship Between the Free and Total Methotrexate Plasma Concentration in Children and Application to Predict the Toxicity of HD-MTX

High-dose methotrexate (HD-MTX) can be highly effective as well as extremely toxic. Many drug molecules can bind to plasma proteins to different extents in vivo, whereas only the free drug can reach the site of action to exert a pharmacological effect and cause toxicity. However, free MTX concentrat...

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Detalles Bibliográficos
Autores principales:	Dong, Wei-Chong, Guo, Jia-Liang, Wu, Xi-Kun, Zhao, Meng-Qiang, Li, Hao-Ran, Zhang, Zhi-Qing, Jiang, Ye
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118665/ https://www.ncbi.nlm.nih.gov/pubmed/33995039 http://dx.doi.org/10.3389/fphar.2021.636975

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