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Systematic screening for a proximal DVT in COVID-19 hospitalized patients: Results of a comparative study

INTRODUCTION: The COVID-19 pandemic is associated with a high incidence of venous thromboembolism questioning the utility of a systematic screening for deep venous thrombosis (DVT) in hospitalised patients. METHODS: In this prospective bicentric controlled study, 4-point ultrasound using a pocket de...

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Autores principales: Fares, Y., Sinzogan-Eyoum, Y.C., Billoir, P., Bogaert, A., Armengol, G., Alexandre, K., Lammens, J., Grall, M., Levesque, H., Benhamou, Y., Miranda, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Masson SAS. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118667/
https://www.ncbi.nlm.nih.gov/pubmed/34238510
http://dx.doi.org/10.1016/j.jdmv.2021.05.003
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author Fares, Y.
Sinzogan-Eyoum, Y.C.
Billoir, P.
Bogaert, A.
Armengol, G.
Alexandre, K.
Lammens, J.
Grall, M.
Levesque, H.
Benhamou, Y.
Miranda, S.
author_facet Fares, Y.
Sinzogan-Eyoum, Y.C.
Billoir, P.
Bogaert, A.
Armengol, G.
Alexandre, K.
Lammens, J.
Grall, M.
Levesque, H.
Benhamou, Y.
Miranda, S.
author_sort Fares, Y.
collection PubMed
description INTRODUCTION: The COVID-19 pandemic is associated with a high incidence of venous thromboembolism questioning the utility of a systematic screening for deep venous thrombosis (DVT) in hospitalised patients. METHODS: In this prospective bicentric controlled study, 4-point ultrasound using a pocket device was used to screen for DVT, in patients with SARS-CoV-2 infection and controls admitted for acute medical illness not related to COVID-19 hospitalised in general ward, in order to assess the utility of a routine screening and to estimate the prevalence of VTE among those patients. RESULTS: Between April and May 2020, 135 patients were screened, 69 in the COVID+ group and 66 in the control one. There was no significant difference in the rate of proximal DVT between the two groups (2.2% vs. 1.5%; P = 0.52), despite the high rate of PE diagnosed among COVID-19 infected patients (10.1% vs. 1.5%, P = 0.063). No isolated DVT was detected, 37.5% of PE was associated with DVT. Mortality (7.2% vs. 1.5%) was not different (P = 0.21) between COVID-19 patients and controls. CONCLUSION: The systematic screening for proximal DVT was not found to be relevant among COVID-19 patients hospitalized in general ward despite the increase of VTE among this population. Further studies are needed to confirm the hypothesis of a local pulmonary thrombosis which may lead to new therapeutic targets.
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spelling pubmed-81186672021-05-14 Systematic screening for a proximal DVT in COVID-19 hospitalized patients: Results of a comparative study Fares, Y. Sinzogan-Eyoum, Y.C. Billoir, P. Bogaert, A. Armengol, G. Alexandre, K. Lammens, J. Grall, M. Levesque, H. Benhamou, Y. Miranda, S. J Med Vasc Original Article INTRODUCTION: The COVID-19 pandemic is associated with a high incidence of venous thromboembolism questioning the utility of a systematic screening for deep venous thrombosis (DVT) in hospitalised patients. METHODS: In this prospective bicentric controlled study, 4-point ultrasound using a pocket device was used to screen for DVT, in patients with SARS-CoV-2 infection and controls admitted for acute medical illness not related to COVID-19 hospitalised in general ward, in order to assess the utility of a routine screening and to estimate the prevalence of VTE among those patients. RESULTS: Between April and May 2020, 135 patients were screened, 69 in the COVID+ group and 66 in the control one. There was no significant difference in the rate of proximal DVT between the two groups (2.2% vs. 1.5%; P = 0.52), despite the high rate of PE diagnosed among COVID-19 infected patients (10.1% vs. 1.5%, P = 0.063). No isolated DVT was detected, 37.5% of PE was associated with DVT. Mortality (7.2% vs. 1.5%) was not different (P = 0.21) between COVID-19 patients and controls. CONCLUSION: The systematic screening for proximal DVT was not found to be relevant among COVID-19 patients hospitalized in general ward despite the increase of VTE among this population. Further studies are needed to confirm the hypothesis of a local pulmonary thrombosis which may lead to new therapeutic targets. Published by Elsevier Masson SAS. 2021-07 2021-05-14 /pmc/articles/PMC8118667/ /pubmed/34238510 http://dx.doi.org/10.1016/j.jdmv.2021.05.003 Text en © 2021 Published by Elsevier Masson SAS. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Fares, Y.
Sinzogan-Eyoum, Y.C.
Billoir, P.
Bogaert, A.
Armengol, G.
Alexandre, K.
Lammens, J.
Grall, M.
Levesque, H.
Benhamou, Y.
Miranda, S.
Systematic screening for a proximal DVT in COVID-19 hospitalized patients: Results of a comparative study
title Systematic screening for a proximal DVT in COVID-19 hospitalized patients: Results of a comparative study
title_full Systematic screening for a proximal DVT in COVID-19 hospitalized patients: Results of a comparative study
title_fullStr Systematic screening for a proximal DVT in COVID-19 hospitalized patients: Results of a comparative study
title_full_unstemmed Systematic screening for a proximal DVT in COVID-19 hospitalized patients: Results of a comparative study
title_short Systematic screening for a proximal DVT in COVID-19 hospitalized patients: Results of a comparative study
title_sort systematic screening for a proximal dvt in covid-19 hospitalized patients: results of a comparative study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118667/
https://www.ncbi.nlm.nih.gov/pubmed/34238510
http://dx.doi.org/10.1016/j.jdmv.2021.05.003
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