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Synthesis and antiviral activity of nonannulated tetrazolylpyrimidines

[Image: see text] Nonannulated tetrazolylpyrimidines in the structure of which the heterocyclic fragments are separated by hydrazinocarbonylmethyl, methylpyrazolyl groups or a sulfur atom were synthesized. Some of these compounds showed moderate in vitro activity against H1N1 subtype of influenza A...

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Detalles Bibliográficos
Autores principales: Ostrovskii, Vladimir А., Danagulyan, Gevorg G., Nesterova, Olga M., Pavlyukova, Yulia N., Tolstyakov, Vladimir V., Zarubina, Olga S., Slepukhin, Pavel А., Esaulkova, Yana L., Muryleva, Anna А., Zarubaev, Vladimir V., Trifonov, Rostislav E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118680/
https://www.ncbi.nlm.nih.gov/pubmed/34007083
http://dx.doi.org/10.1007/s10593-021-02922-6
Descripción
Sumario:[Image: see text] Nonannulated tetrazolylpyrimidines in the structure of which the heterocyclic fragments are separated by hydrazinocarbonylmethyl, methylpyrazolyl groups or a sulfur atom were synthesized. Some of these compounds showed moderate in vitro activity against H1N1 subtype of influenza A virus. The selectivity index of the anti-influenza action of {5-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-1H-tetrazol-1-yl}acetic acid, which has very low cytotoxicity, was twice as high as the selectivity index of the reference drug rimantadine.