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Q493K and Q498H substitutions in Spike promote adaptation of SARS-CoV-2 in mice

BACKGROUND: An ideal animal model to study SARS-coronavirus 2 (SARS-CoV-2) pathogenesis and evaluate therapies and vaccines should reproduce SARS-CoV-2 infection and recapitulate lung disease like those seen in humans. The angiotensin-converting enzyme 2 (ACE2) is a functional receptor for SARS-CoV-...

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Detalles Bibliográficos
Autores principales:	Huang, Kun, Zhang, Yufei, Hui, Xianfeng, Zhao, Ya, Gong, Wenxiao, Wang, Ting, Zhang, Shaoran, Yang, Yong, Deng, Fei, Zhang, Qiang, Chen, Xi, Yang, Ying, Sun, Xiaomei, Chen, Huanchun, Tao, Yizhi J., Zou, Zhong, Jin, Meilin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118724/ https://www.ncbi.nlm.nih.gov/pubmed/33993052 http://dx.doi.org/10.1016/j.ebiom.2021.103381

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