Cargando…

Preliminary Comparison of Subcortical Structures in Elderly Subclinical Depression: Structural Analysis with 3T MRI

Depression in the elderly population has shown increased likelihood of neurological disorders due to structural changes in the subcortical area. However, further investigation into depression related subcortical changes is needed due to mismatches in structural analysis results between studies as we...

Descripción completa

Detalles Bibliográficos
Autores principales: Im, SangJin, Lee, Jeonghwan, Kim, Siekyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Brain and Neural Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118753/
https://www.ncbi.nlm.nih.gov/pubmed/33972469
http://dx.doi.org/10.5607/en20056
_version_ 1783691812732403712
author Im, SangJin
Lee, Jeonghwan
Kim, Siekyeong
author_facet Im, SangJin
Lee, Jeonghwan
Kim, Siekyeong
author_sort Im, SangJin
collection PubMed
description Depression in the elderly population has shown increased likelihood of neurological disorders due to structural changes in the subcortical area. However, further investigation into depression related subcortical changes is needed due to mismatches in structural analysis results between studies as well as scarcities in research regarding subcortical connectivity patterns of subclinical depression populations. This study aims to investigate structural differences in subcortical regions of aged participants with subclinical depression using 3Tesla MRI. In structural analysis, volumes of each subcortical region were measured to observe the volumetric difference and asymmetry between groups, but no significant difference was found. In addition, fractional anisotropy (FA) and apparent diffusion coefficient (ADC) did not show any significant differences between groups. Structural analysis using probabilistic tractography indicated that the connection strength between left nucleus accumbens-right hippocampus, and right thalamus-right caudate was higher in the control group than the subclinical depression group. The differences in subcortical connection strength of subclinical depression groups, have shown to correlate with emotional and cognitive disorders, such as anxiety and memory impairment. We believe that the analysis of structural differences and cross-regional network measures in subcortical structures can help identify neurophysiological changes occurring in subclinical depression.
format Online
Article
Text
id pubmed-8118753
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Korean Society for Brain and Neural Sciences
record_format MEDLINE/PubMed
spelling pubmed-81187532021-05-24 Preliminary Comparison of Subcortical Structures in Elderly Subclinical Depression: Structural Analysis with 3T MRI Im, SangJin Lee, Jeonghwan Kim, Siekyeong Exp Neurobiol Original Article Depression in the elderly population has shown increased likelihood of neurological disorders due to structural changes in the subcortical area. However, further investigation into depression related subcortical changes is needed due to mismatches in structural analysis results between studies as well as scarcities in research regarding subcortical connectivity patterns of subclinical depression populations. This study aims to investigate structural differences in subcortical regions of aged participants with subclinical depression using 3Tesla MRI. In structural analysis, volumes of each subcortical region were measured to observe the volumetric difference and asymmetry between groups, but no significant difference was found. In addition, fractional anisotropy (FA) and apparent diffusion coefficient (ADC) did not show any significant differences between groups. Structural analysis using probabilistic tractography indicated that the connection strength between left nucleus accumbens-right hippocampus, and right thalamus-right caudate was higher in the control group than the subclinical depression group. The differences in subcortical connection strength of subclinical depression groups, have shown to correlate with emotional and cognitive disorders, such as anxiety and memory impairment. We believe that the analysis of structural differences and cross-regional network measures in subcortical structures can help identify neurophysiological changes occurring in subclinical depression. The Korean Society for Brain and Neural Sciences 2021-04-30 2021-04-30 /pmc/articles/PMC8118753/ /pubmed/33972469 http://dx.doi.org/10.5607/en20056 Text en Copyright © Experimental Neurobiology 2021 https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Im, SangJin
Lee, Jeonghwan
Kim, Siekyeong
Preliminary Comparison of Subcortical Structures in Elderly Subclinical Depression: Structural Analysis with 3T MRI
title Preliminary Comparison of Subcortical Structures in Elderly Subclinical Depression: Structural Analysis with 3T MRI
title_full Preliminary Comparison of Subcortical Structures in Elderly Subclinical Depression: Structural Analysis with 3T MRI
title_fullStr Preliminary Comparison of Subcortical Structures in Elderly Subclinical Depression: Structural Analysis with 3T MRI
title_full_unstemmed Preliminary Comparison of Subcortical Structures in Elderly Subclinical Depression: Structural Analysis with 3T MRI
title_short Preliminary Comparison of Subcortical Structures in Elderly Subclinical Depression: Structural Analysis with 3T MRI
title_sort preliminary comparison of subcortical structures in elderly subclinical depression: structural analysis with 3t mri
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8118753/
https://www.ncbi.nlm.nih.gov/pubmed/33972469
http://dx.doi.org/10.5607/en20056
work_keys_str_mv AT imsangjin preliminarycomparisonofsubcorticalstructuresinelderlysubclinicaldepressionstructuralanalysiswith3tmri
AT leejeonghwan preliminarycomparisonofsubcorticalstructuresinelderlysubclinicaldepressionstructuralanalysiswith3tmri
AT kimsiekyeong preliminarycomparisonofsubcorticalstructuresinelderlysubclinicaldepressionstructuralanalysiswith3tmri