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SIRT3 is required for liver regeneration but not for the beneficial effect of nicotinamide riboside

Liver regeneration is critical to survival after traumatic injuries, exposure to hepatotoxins, or surgical interventions, yet the underlying signaling and metabolic pathways remain unclear. In this study, we show that hepatocyte-specific loss of the mitochondrial deacetylase SIRT3 drastically impair...

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Detalles Bibliográficos
Autores principales:	Mukherjee, Sarmistha, Mo, James, Paolella, Lauren M., Perry, Caroline E., Toth, Jade, Hugo, Mindy M., Chu, Qingwei, Tong, Qiang, Chellappa, Karthikeyani, Baur, Joseph A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119200/ https://www.ncbi.nlm.nih.gov/pubmed/33690226 http://dx.doi.org/10.1172/jci.insight.147193

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