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Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses

Anastomotic leakage (AL) accounts for a major part of in-house mortality in patients undergoing colorectal surgery. Local ischemia and abdominal sepsis are common risk factors contributing to AL and are characterized by upregulation of the hypoxia-inducible factor (HIF) pathway. The HIF pathway is c...

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Detalles Bibliográficos
Autores principales:	Strowitzki, Moritz J., Kimmer, Gwendolyn, Wehrmann, Julian, Ritter, Alina S., Radhakrishnan, Praveen, Opitz, Vanessa M., Tuffs, Christopher, Biller, Marvin, Kugler, Julia, Keppler, Ulrich, Harnoss, Jonathan M., Klose, Johannes, Schmidt, Thomas, Blanco, Alfonso, Taylor, Cormac T., Schneider, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119215/ https://www.ncbi.nlm.nih.gov/pubmed/33784253 http://dx.doi.org/10.1172/jci.insight.139191

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