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Hypoxia and viral infectious diseases
Oxygen-sensing mechanisms allow cells to adapt and respond to changes in cellular oxygen tension, including hypoxic conditions. Hypoxia-inducible factor (HIF) is a central mediator in this fundamental adaptive response, and has critical functions in normal and disease physiology. Viruses have been s...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119216/ https://www.ncbi.nlm.nih.gov/pubmed/33830079 http://dx.doi.org/10.1172/jci.insight.147190 |
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author | Huang, Richard Huestis, Melissa Gan, Esther Shuyi Ooi, Eng Eong Ohh, Michael |
author_facet | Huang, Richard Huestis, Melissa Gan, Esther Shuyi Ooi, Eng Eong Ohh, Michael |
author_sort | Huang, Richard |
collection | PubMed |
description | Oxygen-sensing mechanisms allow cells to adapt and respond to changes in cellular oxygen tension, including hypoxic conditions. Hypoxia-inducible factor (HIF) is a central mediator in this fundamental adaptive response, and has critical functions in normal and disease physiology. Viruses have been shown to manipulate HIFs during their life cycle to facilitate replication and invasion. Conversely, HIFs are also implicated in the development of the host immune system and response to viral infections. Here, we highlight the recent revelations of host-pathogen interactions that involve the hypoxic response pathway and the role of HIF in emerging viral infectious diseases, as well as discussing potential antiviral therapeutic strategies targeting the HIF signaling axis. |
format | Online Article Text |
id | pubmed-8119216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Society for Clinical Investigation |
record_format | MEDLINE/PubMed |
spelling | pubmed-81192162021-05-18 Hypoxia and viral infectious diseases Huang, Richard Huestis, Melissa Gan, Esther Shuyi Ooi, Eng Eong Ohh, Michael JCI Insight Review Oxygen-sensing mechanisms allow cells to adapt and respond to changes in cellular oxygen tension, including hypoxic conditions. Hypoxia-inducible factor (HIF) is a central mediator in this fundamental adaptive response, and has critical functions in normal and disease physiology. Viruses have been shown to manipulate HIFs during their life cycle to facilitate replication and invasion. Conversely, HIFs are also implicated in the development of the host immune system and response to viral infections. Here, we highlight the recent revelations of host-pathogen interactions that involve the hypoxic response pathway and the role of HIF in emerging viral infectious diseases, as well as discussing potential antiviral therapeutic strategies targeting the HIF signaling axis. American Society for Clinical Investigation 2021-04-08 /pmc/articles/PMC8119216/ /pubmed/33830079 http://dx.doi.org/10.1172/jci.insight.147190 Text en © 2021 Huang et al. https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Huang, Richard Huestis, Melissa Gan, Esther Shuyi Ooi, Eng Eong Ohh, Michael Hypoxia and viral infectious diseases |
title | Hypoxia and viral infectious diseases |
title_full | Hypoxia and viral infectious diseases |
title_fullStr | Hypoxia and viral infectious diseases |
title_full_unstemmed | Hypoxia and viral infectious diseases |
title_short | Hypoxia and viral infectious diseases |
title_sort | hypoxia and viral infectious diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119216/ https://www.ncbi.nlm.nih.gov/pubmed/33830079 http://dx.doi.org/10.1172/jci.insight.147190 |
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