Cargando…
Fatty acid binding protein 4 promotes autoimmune diabetes by recruitment and activation of pancreatic islet macrophages
Both innate and adaptive immune cells are critical players in autoimmune destruction of insulin-producing β cells in type 1 diabetes. However, the early pathogenic events triggering the recruitment and activation of innate immune cells in islets remain obscure. Here we show that circulating fatty ac...
Autores principales: | Xiao, Yang, Shu, Lingling, Wu, Xiaoping, Liu, Yang, Cheong, Lai Yee, Liao, Boya, Xiao, Xiaoyu, Hoo, Ruby L.C., Zhou, Zhiguang, Xu, Aimin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119222/ https://www.ncbi.nlm.nih.gov/pubmed/33690220 http://dx.doi.org/10.1172/jci.insight.141814 |
Ejemplares similares
-
Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy
por: Hoo, Ruby L. C., et al.
Publicado: (2017) -
Hepatocyte-Secreted Autotaxin Exacerbates Nonalcoholic Fatty Liver Disease Through Autocrine Inhibition of the PPARα/FGF21 Axis
por: Qiu, Han, et al.
Publicado: (2022) -
Adipocyte Fatty Acid Binding Protein Promotes the Onset and Progression of Liver Fibrosis via Mediating the Crosstalk between Liver Sinusoidal Endothelial Cells and Hepatic Stellate Cells
por: Wu, Xiaoping, et al.
Publicado: (2021) -
A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes
por: Shu, Lingling, et al.
Publicado: (2017) -
Adipocyte fatty acid-binding protein exacerbates cerebral ischaemia injury by disrupting the blood–brain barrier
por: Liao, Boya, et al.
Publicado: (2020)