A human Myogenin promoter modified to be highly active in alveolar rhabdomyosarcoma drives an effective suicide gene therapy

Rhabdomyosarcoma is a rare childhood soft tissue cancer whose cells resemble poorly differentiated skeletal muscle, expressing myogenic proteins including MYOGENIN. Alveolar rhabdomyosarcoma (ARMS) accounts for ~40% of cases and is associated with a poorer prognosis than other rhabdomyosarcoma varia...

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Detalles Bibliográficos
Autores principales: Pruller, Johanna, Hofer, Isabella, Ganassi, Massimo, Heher, Philipp, Ma, Michelle T., Zammit, Peter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119243/
https://www.ncbi.nlm.nih.gov/pubmed/32973362
http://dx.doi.org/10.1038/s41417-020-00225-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119243/
https://www.ncbi.nlm.nih.gov/pubmed/32973362
http://dx.doi.org/10.1038/s41417-020-00225-0

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