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Defining early recurrence in patients with resected primary colorectal carcinoma and its respective risk factors
PURPOSE: There is no evidence-based definition of early recurrence following resection of colorectal cancer. The purpose of this study is to define a point that discriminates between early and late recurrence in patients who have undergone colorectal cancer resection with curative intent and to anal...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119399/ https://www.ncbi.nlm.nih.gov/pubmed/33449131 http://dx.doi.org/10.1007/s00384-021-03844-7 |
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author | Wiesmueller, Felix Schuetz, Rolf Langheinrich, Melanie Brunner, Maximilian Weber, Georg F. Grützmann, Robert Merkel, Susanne Krautz, Christian |
author_facet | Wiesmueller, Felix Schuetz, Rolf Langheinrich, Melanie Brunner, Maximilian Weber, Georg F. Grützmann, Robert Merkel, Susanne Krautz, Christian |
author_sort | Wiesmueller, Felix |
collection | PubMed |
description | PURPOSE: There is no evidence-based definition of early recurrence following resection of colorectal cancer. The purpose of this study is to define a point that discriminates between early and late recurrence in patients who have undergone colorectal cancer resection with curative intent and to analyze associated risk factors. METHODS: A retrospective single-center cohort study was performed at a university hospital recognized as a comprehensive cancer center, specializing in colorectal cancer surgery. Patient data were retrieved from a prospectively maintained institutional database. Included patients underwent resection for primary, non-metastatic colorectal carcinomas with curative intent between 1995 and 2010. Aims of the study were (1) to define the optimal cut-off point of recurrence-free survival based on overall survival using a minimum p value approach and (2) to identify patterns of initial recurrence and putative risk factors for early recurrence using regression models. RESULTS: Recurrence was diagnosed in 412 of 1893 patients. Statistical analysis suggested that a recurrence-free survival of 16 months could be used to distinguish between early and late recurrence based on overall survival (p < 0.001). Independent risk factors for early recurrence included advanced pT categories (pT3,4/ypT3,4) and positive lymph node status (pN+/ypN+). Early recurrence was independent of site of recurrence and was associated with worse prognosis. CONCLUSIONS: Recurrence of colorectal carcinoma within 16 months after primary treatment should be labeled as “early.” Tumor categories pT3,4/ypT3,4 and positive lymph node status pN+/ypN+ are predictive of early recurrence. |
format | Online Article Text |
id | pubmed-8119399 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-81193992021-05-18 Defining early recurrence in patients with resected primary colorectal carcinoma and its respective risk factors Wiesmueller, Felix Schuetz, Rolf Langheinrich, Melanie Brunner, Maximilian Weber, Georg F. Grützmann, Robert Merkel, Susanne Krautz, Christian Int J Colorectal Dis Original Article PURPOSE: There is no evidence-based definition of early recurrence following resection of colorectal cancer. The purpose of this study is to define a point that discriminates between early and late recurrence in patients who have undergone colorectal cancer resection with curative intent and to analyze associated risk factors. METHODS: A retrospective single-center cohort study was performed at a university hospital recognized as a comprehensive cancer center, specializing in colorectal cancer surgery. Patient data were retrieved from a prospectively maintained institutional database. Included patients underwent resection for primary, non-metastatic colorectal carcinomas with curative intent between 1995 and 2010. Aims of the study were (1) to define the optimal cut-off point of recurrence-free survival based on overall survival using a minimum p value approach and (2) to identify patterns of initial recurrence and putative risk factors for early recurrence using regression models. RESULTS: Recurrence was diagnosed in 412 of 1893 patients. Statistical analysis suggested that a recurrence-free survival of 16 months could be used to distinguish between early and late recurrence based on overall survival (p < 0.001). Independent risk factors for early recurrence included advanced pT categories (pT3,4/ypT3,4) and positive lymph node status (pN+/ypN+). Early recurrence was independent of site of recurrence and was associated with worse prognosis. CONCLUSIONS: Recurrence of colorectal carcinoma within 16 months after primary treatment should be labeled as “early.” Tumor categories pT3,4/ypT3,4 and positive lymph node status pN+/ypN+ are predictive of early recurrence. Springer Berlin Heidelberg 2021-01-15 2021 /pmc/articles/PMC8119399/ /pubmed/33449131 http://dx.doi.org/10.1007/s00384-021-03844-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Wiesmueller, Felix Schuetz, Rolf Langheinrich, Melanie Brunner, Maximilian Weber, Georg F. Grützmann, Robert Merkel, Susanne Krautz, Christian Defining early recurrence in patients with resected primary colorectal carcinoma and its respective risk factors |
title | Defining early recurrence in patients with resected primary colorectal carcinoma and its respective risk factors |
title_full | Defining early recurrence in patients with resected primary colorectal carcinoma and its respective risk factors |
title_fullStr | Defining early recurrence in patients with resected primary colorectal carcinoma and its respective risk factors |
title_full_unstemmed | Defining early recurrence in patients with resected primary colorectal carcinoma and its respective risk factors |
title_short | Defining early recurrence in patients with resected primary colorectal carcinoma and its respective risk factors |
title_sort | defining early recurrence in patients with resected primary colorectal carcinoma and its respective risk factors |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119399/ https://www.ncbi.nlm.nih.gov/pubmed/33449131 http://dx.doi.org/10.1007/s00384-021-03844-7 |
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