Antigen-specific antibody and polyfunctional T cells generated by respiratory immunization with protective BurkholderiaΔtonBΔhcp1 live attenuated vaccines

Melioidosis, caused by Burkholderia pseudomallei (Bpm), lacks a vaccine. We identify the immune correlates of protection induced by B. mallei ΔtonB Δhcp1 (CLH001) and Bpm ΔtonB Δhcp1 (PBK001) vaccines against inhalational melioidosis. Mucosal immunization with either vaccine generates Bpm-specific I...

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Detalles Bibliográficos
Autores principales: Khakhum, Nittaya, Bharaj, Preeti, Walker, David H., Torres, Alfredo G., Endsley, Janice J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119421/
https://www.ncbi.nlm.nih.gov/pubmed/33986290
http://dx.doi.org/10.1038/s41541-021-00333-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119421/
https://www.ncbi.nlm.nih.gov/pubmed/33986290
http://dx.doi.org/10.1038/s41541-021-00333-4

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