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Antigen-specific antibody and polyfunctional T cells generated by respiratory immunization with protective BurkholderiaΔtonBΔhcp1 live attenuated vaccines

Melioidosis, caused by Burkholderia pseudomallei (Bpm), lacks a vaccine. We identify the immune correlates of protection induced by B. mallei ΔtonB Δhcp1 (CLH001) and Bpm ΔtonB Δhcp1 (PBK001) vaccines against inhalational melioidosis. Mucosal immunization with either vaccine generates Bpm-specific I...

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Detalles Bibliográficos
Autores principales:	Khakhum, Nittaya, Bharaj, Preeti, Walker, David H., Torres, Alfredo G., Endsley, Janice J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119421/ https://www.ncbi.nlm.nih.gov/pubmed/33986290 http://dx.doi.org/10.1038/s41541-021-00333-4

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