Cargando…

Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease

Conflicting results have been reported regarding the effectiveness of light treatment (LT) in patients with Alzheimer’s disease (AD). We investigated the effectiveness of blue-enriched white LT on sleep, cognition, mood and behavior in patients with mild and moderate AD. The treatment group (n = 14)...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Seong Jae, Lee, Sun Hee, Suh, In Bum, Jang, Jae-Won, Jhoo, Jin Hyeong, Lee, Jung Hie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119443/
https://www.ncbi.nlm.nih.gov/pubmed/33986349
http://dx.doi.org/10.1038/s41598-021-89521-9
_version_ 1783691856784130048
author Kim, Seong Jae
Lee, Sun Hee
Suh, In Bum
Jang, Jae-Won
Jhoo, Jin Hyeong
Lee, Jung Hie
author_facet Kim, Seong Jae
Lee, Sun Hee
Suh, In Bum
Jang, Jae-Won
Jhoo, Jin Hyeong
Lee, Jung Hie
author_sort Kim, Seong Jae
collection PubMed
description Conflicting results have been reported regarding the effectiveness of light treatment (LT) in patients with Alzheimer’s disease (AD). We investigated the effectiveness of blue-enriched white LT on sleep, cognition, mood and behavior in patients with mild and moderate AD. The treatment group (n = 14) sat about 60 cm away from a small (136 × 73 × 16 mm) LED light box for 1 h each morning for 2 weeks. The control group (n = 11) wore dark, blue-attenuating sunglasses during the 1 h exposures. The morning light started 9–10 h after each individual’s dim light melatonin onset (DLMO). Assessments were done at baseline (T0), immediate post-treatment (T1), and 4 weeks after the end of the 2 weeks of LT (T2). Sleep was measured by actigraphy. Blue-enriched LT had a significantly better effect on the Pittsburgh Sleep Quality Index at T2 compared to blue-attenuated LT, and a trend of better effectiveness on total sleep time at T2. There was a significant increase in Mini-Mental State Examination score at T2 after blue-enriched LT than that at T0. Our findings suggest that morning blue-enriched LT has a benefit in improving sleep and cognitive function in AD patients.
format Online
Article
Text
id pubmed-8119443
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-81194432021-05-14 Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease Kim, Seong Jae Lee, Sun Hee Suh, In Bum Jang, Jae-Won Jhoo, Jin Hyeong Lee, Jung Hie Sci Rep Article Conflicting results have been reported regarding the effectiveness of light treatment (LT) in patients with Alzheimer’s disease (AD). We investigated the effectiveness of blue-enriched white LT on sleep, cognition, mood and behavior in patients with mild and moderate AD. The treatment group (n = 14) sat about 60 cm away from a small (136 × 73 × 16 mm) LED light box for 1 h each morning for 2 weeks. The control group (n = 11) wore dark, blue-attenuating sunglasses during the 1 h exposures. The morning light started 9–10 h after each individual’s dim light melatonin onset (DLMO). Assessments were done at baseline (T0), immediate post-treatment (T1), and 4 weeks after the end of the 2 weeks of LT (T2). Sleep was measured by actigraphy. Blue-enriched LT had a significantly better effect on the Pittsburgh Sleep Quality Index at T2 compared to blue-attenuated LT, and a trend of better effectiveness on total sleep time at T2. There was a significant increase in Mini-Mental State Examination score at T2 after blue-enriched LT than that at T0. Our findings suggest that morning blue-enriched LT has a benefit in improving sleep and cognitive function in AD patients. Nature Publishing Group UK 2021-05-13 /pmc/articles/PMC8119443/ /pubmed/33986349 http://dx.doi.org/10.1038/s41598-021-89521-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kim, Seong Jae
Lee, Sun Hee
Suh, In Bum
Jang, Jae-Won
Jhoo, Jin Hyeong
Lee, Jung Hie
Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease
title Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease
title_full Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease
title_fullStr Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease
title_full_unstemmed Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease
title_short Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease
title_sort positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate alzheimer’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119443/
https://www.ncbi.nlm.nih.gov/pubmed/33986349
http://dx.doi.org/10.1038/s41598-021-89521-9
work_keys_str_mv AT kimseongjae positiveeffectoftimedblueenrichedwhitelightonsleepandcognitioninpatientswithmildandmoderatealzheimersdisease
AT leesunhee positiveeffectoftimedblueenrichedwhitelightonsleepandcognitioninpatientswithmildandmoderatealzheimersdisease
AT suhinbum positiveeffectoftimedblueenrichedwhitelightonsleepandcognitioninpatientswithmildandmoderatealzheimersdisease
AT jangjaewon positiveeffectoftimedblueenrichedwhitelightonsleepandcognitioninpatientswithmildandmoderatealzheimersdisease
AT jhoojinhyeong positiveeffectoftimedblueenrichedwhitelightonsleepandcognitioninpatientswithmildandmoderatealzheimersdisease
AT leejunghie positiveeffectoftimedblueenrichedwhitelightonsleepandcognitioninpatientswithmildandmoderatealzheimersdisease