Cargando…
Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease
Conflicting results have been reported regarding the effectiveness of light treatment (LT) in patients with Alzheimer’s disease (AD). We investigated the effectiveness of blue-enriched white LT on sleep, cognition, mood and behavior in patients with mild and moderate AD. The treatment group (n = 14)...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119443/ https://www.ncbi.nlm.nih.gov/pubmed/33986349 http://dx.doi.org/10.1038/s41598-021-89521-9 |
_version_ | 1783691856784130048 |
---|---|
author | Kim, Seong Jae Lee, Sun Hee Suh, In Bum Jang, Jae-Won Jhoo, Jin Hyeong Lee, Jung Hie |
author_facet | Kim, Seong Jae Lee, Sun Hee Suh, In Bum Jang, Jae-Won Jhoo, Jin Hyeong Lee, Jung Hie |
author_sort | Kim, Seong Jae |
collection | PubMed |
description | Conflicting results have been reported regarding the effectiveness of light treatment (LT) in patients with Alzheimer’s disease (AD). We investigated the effectiveness of blue-enriched white LT on sleep, cognition, mood and behavior in patients with mild and moderate AD. The treatment group (n = 14) sat about 60 cm away from a small (136 × 73 × 16 mm) LED light box for 1 h each morning for 2 weeks. The control group (n = 11) wore dark, blue-attenuating sunglasses during the 1 h exposures. The morning light started 9–10 h after each individual’s dim light melatonin onset (DLMO). Assessments were done at baseline (T0), immediate post-treatment (T1), and 4 weeks after the end of the 2 weeks of LT (T2). Sleep was measured by actigraphy. Blue-enriched LT had a significantly better effect on the Pittsburgh Sleep Quality Index at T2 compared to blue-attenuated LT, and a trend of better effectiveness on total sleep time at T2. There was a significant increase in Mini-Mental State Examination score at T2 after blue-enriched LT than that at T0. Our findings suggest that morning blue-enriched LT has a benefit in improving sleep and cognitive function in AD patients. |
format | Online Article Text |
id | pubmed-8119443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-81194432021-05-14 Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease Kim, Seong Jae Lee, Sun Hee Suh, In Bum Jang, Jae-Won Jhoo, Jin Hyeong Lee, Jung Hie Sci Rep Article Conflicting results have been reported regarding the effectiveness of light treatment (LT) in patients with Alzheimer’s disease (AD). We investigated the effectiveness of blue-enriched white LT on sleep, cognition, mood and behavior in patients with mild and moderate AD. The treatment group (n = 14) sat about 60 cm away from a small (136 × 73 × 16 mm) LED light box for 1 h each morning for 2 weeks. The control group (n = 11) wore dark, blue-attenuating sunglasses during the 1 h exposures. The morning light started 9–10 h after each individual’s dim light melatonin onset (DLMO). Assessments were done at baseline (T0), immediate post-treatment (T1), and 4 weeks after the end of the 2 weeks of LT (T2). Sleep was measured by actigraphy. Blue-enriched LT had a significantly better effect on the Pittsburgh Sleep Quality Index at T2 compared to blue-attenuated LT, and a trend of better effectiveness on total sleep time at T2. There was a significant increase in Mini-Mental State Examination score at T2 after blue-enriched LT than that at T0. Our findings suggest that morning blue-enriched LT has a benefit in improving sleep and cognitive function in AD patients. Nature Publishing Group UK 2021-05-13 /pmc/articles/PMC8119443/ /pubmed/33986349 http://dx.doi.org/10.1038/s41598-021-89521-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Kim, Seong Jae Lee, Sun Hee Suh, In Bum Jang, Jae-Won Jhoo, Jin Hyeong Lee, Jung Hie Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease |
title | Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease |
title_full | Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease |
title_fullStr | Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease |
title_full_unstemmed | Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease |
title_short | Positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate Alzheimer’s disease |
title_sort | positive effect of timed blue-enriched white light on sleep and cognition in patients with mild and moderate alzheimer’s disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119443/ https://www.ncbi.nlm.nih.gov/pubmed/33986349 http://dx.doi.org/10.1038/s41598-021-89521-9 |
work_keys_str_mv | AT kimseongjae positiveeffectoftimedblueenrichedwhitelightonsleepandcognitioninpatientswithmildandmoderatealzheimersdisease AT leesunhee positiveeffectoftimedblueenrichedwhitelightonsleepandcognitioninpatientswithmildandmoderatealzheimersdisease AT suhinbum positiveeffectoftimedblueenrichedwhitelightonsleepandcognitioninpatientswithmildandmoderatealzheimersdisease AT jangjaewon positiveeffectoftimedblueenrichedwhitelightonsleepandcognitioninpatientswithmildandmoderatealzheimersdisease AT jhoojinhyeong positiveeffectoftimedblueenrichedwhitelightonsleepandcognitioninpatientswithmildandmoderatealzheimersdisease AT leejunghie positiveeffectoftimedblueenrichedwhitelightonsleepandcognitioninpatientswithmildandmoderatealzheimersdisease |