Cargando…

Hyperbaric oxygen promotes not only glioblastoma proliferation but also chemosensitization by inhibiting HIF1α/HIF2α-Sox2

There exists a consensus that combining hyperbaric oxygen (HBO) and chemotherapy promotes chemotherapy sensitivity in GBM cells. However, few studies have explored the mechanism involved. HIF1α and HIF2α are the two main molecules that contribute to GBM malignant progression by inhibiting apoptosis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Pan, Gong, Sheng, Pan, Jinyu, Wang, Junwei, Zou, Dewei, Xiong, Shuanglong, Zhao, Lu, Yan, Qian, Deng, Yangming, Wu, Nan, Liao, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119469/ https://www.ncbi.nlm.nih.gov/pubmed/33986256 http://dx.doi.org/10.1038/s41420-021-00486-0

Ejemplares similares

HIF1α/HIF2α induces glioma cell dedifferentiation into cancer stem cells through Sox2 under hypoxic conditions
por: Wang, Pan, et al.
Publicado: (2022)

HIF1α/HIF2α–Sox2/Klf4 promotes the malignant progression of glioblastoma via the EGFR–PI3K/AKT signalling pathway with positive feedback under hypoxia
por: Wang, Pan, et al.
Publicado: (2021)

The HIF1α/HIF2α-miR210-3p network regulates glioblastoma cell proliferation, dedifferentiation and chemoresistance through EGF under hypoxic conditions
por: Wang, Pan, et al.
Publicado: (2020)

HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels
por: Wang, Pan, et al.
Publicado: (2017)

Expression of HIF-1α and HIF-2α correlates to biological and clinical significance in papillary thyroid carcinoma
por: Liu, Yan-Mei, et al.
Publicado: (2016)

HIF1α regulates single differentiated glioma cell dedifferentiation to stem-like cell phenotypes with high tumorigenic potential under hypoxia
por: Wang, Pan, et al.
Publicado: (2017)

Association of Age with the Expression of Hypoxia-Inducible Factors HIF-1α, HIF-2α, HIF-3α and VEGF in Lung and Heart of Tibetan Sheep
por: He, Yanyu, et al.
Publicado: (2019)

Electroacupuncture Upregulates HIF-1α and SOX9 Expression in Knee Osteoarthritis
por: Tong, Jie, et al.
Publicado: (2021)

Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success
por: Branco-Price, Cristina, et al.
Publicado: (2012)

HIF1α and HIF2α Exert Distinct Nutrient Preferences in Renal Cells
por: Arreola, Alexandra, et al.
Publicado: (2014)

HIF-1α and HIF-2α Differently Regulate the Radiation Sensitivity of NSCLC Cells
por: Moreno Roig, Eloy, et al.
Publicado: (2019)

HIF-2α is indispensable for regulatory T cell function
por: Hsu, Tzu-Sheng, et al.
Publicado: (2020)

Targeting HIF-2α in the Tumor Microenvironment: Redefining the Role of HIF-2α for Solid Cancer Therapy
por: Davis, Leah, et al.
Publicado: (2022)

Gene silencing of HIF-2α disrupts glioblastoma stem cell phenotype
por: Nusblat, Leora M., et al.
Publicado: (2020)

Role of SOX9 and Hif-1α expression in placentas of patients with HELLP
por: Akalın, Senem Alkan, et al.
Publicado: (2023)

Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance
por: Vukovic, Milica, et al.
Publicado: (2015)

Deterioration of alveolar development in mice with both HIF-3α knockout and HIF-2α knockdown
por: Amin, Firman Zulkifli, et al.
Publicado: (2018)

Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin
por: Smythies, James A, et al.
Publicado: (2018)

HIF-1α and HIF-2α induced angiogenesis in gastrointestinal vascular malformation and reversed by thalidomide
por: Feng, Nan, et al.
Publicado: (2016)

Differential effects of HIF2α antagonist and HIF2α silencing in renal cancer and sensitivity to repurposed drugs
por: Arnaiz, Esther, et al.
Publicado: (2021)

The Effect of HIF-1α siRNA on Growth and Chemosensitivity of Mia-paca Cell Line
por: Yang, Lily, et al.
Publicado: (2008)

Opposite effects of HIF-1α and HIF-2α on the regulation of IL-8 expression in endothelial cells
por: Florczyk, Urszula, et al.
Publicado: (2011)

Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice
por: Saini, Yogesh, et al.
Publicado: (2015)

Simulation Predicts IGFBP2-HIF1α Interaction Drives Glioblastoma Growth
por: Lin, Ka Wai, et al.
Publicado: (2015)

HIF-transcribed p53 chaperones HIF-1α
por: Madan, Esha, et al.
Publicado: (2019)

Beluga whale pVHL enhances HIF-2α activity via inducing HIF-2α proteasomal degradation under hypoxia
por: Bi, Jianling, et al.
Publicado: (2017)

HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
por: Tarade, Daniel, et al.
Publicado: (2018)

HIF-1α, HIF-2α, and ProExC: diagnostic or prognostic relevance in conjunctival intraepithelial neoplasia?
por: Nuessle, Simone, et al.
Publicado: (2020)

Differential Contribution of N- and C-Terminal Regions of HIF1α and HIF2α to Their Target Gene Selectivity
por: Bouthelier, Antonio, et al.
Publicado: (2020)

Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia
por: AQUINO-GÁLVEZ, ARNOLDO, et al.
Publicado: (2016)

Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α
por: Tarade, Daniel, et al.
Publicado: (2019)

Vhl deletion in renal epithelia causes HIF-1α-dependent, HIF-2α-independent angiogenesis and constitutive diuresis
por: Schönenberger, Désirée, et al.
Publicado: (2016)

Distinct roles for the hypoxia-inducible transcription factors HIF-1α and HIF-2α in human osteoclast formation and function
por: Knowles, Helen J.
Publicado: (2020)

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
por: Wang, Qirui, et al.
Publicado: (2018)

Integration of CNS survival and differentiation by HIF2α
por: Ko, C-Y, et al.
Publicado: (2011)

Stabilization of HIF-2α impacts pancreas growth
por: Flores-Martínez, Alvaro, et al.
Publicado: (2018)

Coxiella burnetii Affects HIF1α Accumulation and HIF1α Target Gene Expression
por: Hayek, Inaya, et al.
Publicado: (2022)

Inhibition of HIF1α and PDK Induces Cell Death of Glioblastoma Multiforme
por: Han, Jiwon Esther, et al.
Publicado: (2017)

Hyperbaric oxygen in animal model of rheumatoid arthritis: Analysis Of HIF-1α, ACPA and IL-17a
por: Harnanik, Titut, et al.
Publicado: (2020)

Effects of HIF-1α and HIF2α on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts
por: Biswas, Swethajit, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_vj6snqc6gscuvtfd0fod0v8o6b