Prevention of D-GalN/LPS-induced ALI by 18β-glycyrrhetinic acid through PXR-mediated inhibition of autophagy degradation

Acute liver injury (ALI) has multiple causes and results in liver dysfunction. Severe or persistent liver injury eventually leads to liver failure and even death. Pregnane X receptor (PXR)-null mice present more severe liver damage and lower rates of autophagy. 18β-glycyrrhetinic acid (GA) has been...

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Detalles Bibliográficos
Autores principales: Wu, Shouyan, Lu, Henglei, Wang, Wenjie, Song, Luyao, Liu, Meng, Cao, Yuhan, Qi, Xinming, Sun, Jianhua, Gong, Likun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119493/
https://www.ncbi.nlm.nih.gov/pubmed/33986260
http://dx.doi.org/10.1038/s41419-021-03768-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119493/
https://www.ncbi.nlm.nih.gov/pubmed/33986260
http://dx.doi.org/10.1038/s41419-021-03768-8

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