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Negative Prognostic Implication of TERT Promoter Mutations in Human Papillomavirus–Negative Tonsillar Squamous Cell Carcinoma Under the New 8th AJCC Staging System

Telomerase reverse transcriptase gene promoter (TERTp) mutation is a potential candidate for pathogenesis and therapeutic target of tonsillar squamous cell carcinomas (TSCCs) in association with human papillomavirus (HPV). Their clinical relevance has not been validated under the new 8th American Jo...

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Autores principales: Kim, Hyunchul, Kwon, Mi Jung, Park, Bumjung, Choi, Hyo Geun, Nam, Eun Sook, Cho, Seong Jin, Min, Kyueng-Whan, Kim, Eun Soo, Hwang, Hee Sung, Hong, Mineui, Koo, Taeryool, Kim, Hyo Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer India 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119516/
https://www.ncbi.nlm.nih.gov/pubmed/33994739
http://dx.doi.org/10.1007/s13193-020-01200-9
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author Kim, Hyunchul
Kwon, Mi Jung
Park, Bumjung
Choi, Hyo Geun
Nam, Eun Sook
Cho, Seong Jin
Min, Kyueng-Whan
Kim, Eun Soo
Hwang, Hee Sung
Hong, Mineui
Koo, Taeryool
Kim, Hyo Jung
author_facet Kim, Hyunchul
Kwon, Mi Jung
Park, Bumjung
Choi, Hyo Geun
Nam, Eun Sook
Cho, Seong Jin
Min, Kyueng-Whan
Kim, Eun Soo
Hwang, Hee Sung
Hong, Mineui
Koo, Taeryool
Kim, Hyo Jung
author_sort Kim, Hyunchul
collection PubMed
description Telomerase reverse transcriptase gene promoter (TERTp) mutation is a potential candidate for pathogenesis and therapeutic target of tonsillar squamous cell carcinomas (TSCCs) in association with human papillomavirus (HPV). Their clinical relevance has not been validated under the new 8th American Joint Committee on Cancer (AJCC) staging system. We analyzed real-time peptide nucleic acid–mediated PCR and sequencing methods (TERTp mutation) and real-time PCR-based assay (HPV) in 80 surgically resected TSCCs. The 8th edition staging system improved the stratification of the early and advanced stages and between T or N categories for overall survival over the 7th edition. TERTp mutation was found in 7.5%, and HPV in 80.0% of the patients. The majority (83.3%) of TERTp mutation cases were HPV-positive TSCCs. Applying the 8th edition staging system, TERTp mutation was an independent factor of poor prognosis for disease-free survival (DFS) in TSCC patients, supporting the clinical significance of TERTp mutation in tonsil cancer. TERTp mutations were also negatively correlated with overall survival and DFS in HPV-negative TSCCs. Conclusively, TERTp mutation provides negative prognostic impact on survival of surgically managed tonsil cancers staged with the AJCC 8th edition.
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spelling pubmed-81195162021-05-14 Negative Prognostic Implication of TERT Promoter Mutations in Human Papillomavirus–Negative Tonsillar Squamous Cell Carcinoma Under the New 8th AJCC Staging System Kim, Hyunchul Kwon, Mi Jung Park, Bumjung Choi, Hyo Geun Nam, Eun Sook Cho, Seong Jin Min, Kyueng-Whan Kim, Eun Soo Hwang, Hee Sung Hong, Mineui Koo, Taeryool Kim, Hyo Jung Indian J Surg Oncol Original Article Telomerase reverse transcriptase gene promoter (TERTp) mutation is a potential candidate for pathogenesis and therapeutic target of tonsillar squamous cell carcinomas (TSCCs) in association with human papillomavirus (HPV). Their clinical relevance has not been validated under the new 8th American Joint Committee on Cancer (AJCC) staging system. We analyzed real-time peptide nucleic acid–mediated PCR and sequencing methods (TERTp mutation) and real-time PCR-based assay (HPV) in 80 surgically resected TSCCs. The 8th edition staging system improved the stratification of the early and advanced stages and between T or N categories for overall survival over the 7th edition. TERTp mutation was found in 7.5%, and HPV in 80.0% of the patients. The majority (83.3%) of TERTp mutation cases were HPV-positive TSCCs. Applying the 8th edition staging system, TERTp mutation was an independent factor of poor prognosis for disease-free survival (DFS) in TSCC patients, supporting the clinical significance of TERTp mutation in tonsil cancer. TERTp mutations were also negatively correlated with overall survival and DFS in HPV-negative TSCCs. Conclusively, TERTp mutation provides negative prognostic impact on survival of surgically managed tonsil cancers staged with the AJCC 8th edition. Springer India 2020-09-05 2021-04 /pmc/articles/PMC8119516/ /pubmed/33994739 http://dx.doi.org/10.1007/s13193-020-01200-9 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Kim, Hyunchul
Kwon, Mi Jung
Park, Bumjung
Choi, Hyo Geun
Nam, Eun Sook
Cho, Seong Jin
Min, Kyueng-Whan
Kim, Eun Soo
Hwang, Hee Sung
Hong, Mineui
Koo, Taeryool
Kim, Hyo Jung
Negative Prognostic Implication of TERT Promoter Mutations in Human Papillomavirus–Negative Tonsillar Squamous Cell Carcinoma Under the New 8th AJCC Staging System
title Negative Prognostic Implication of TERT Promoter Mutations in Human Papillomavirus–Negative Tonsillar Squamous Cell Carcinoma Under the New 8th AJCC Staging System
title_full Negative Prognostic Implication of TERT Promoter Mutations in Human Papillomavirus–Negative Tonsillar Squamous Cell Carcinoma Under the New 8th AJCC Staging System
title_fullStr Negative Prognostic Implication of TERT Promoter Mutations in Human Papillomavirus–Negative Tonsillar Squamous Cell Carcinoma Under the New 8th AJCC Staging System
title_full_unstemmed Negative Prognostic Implication of TERT Promoter Mutations in Human Papillomavirus–Negative Tonsillar Squamous Cell Carcinoma Under the New 8th AJCC Staging System
title_short Negative Prognostic Implication of TERT Promoter Mutations in Human Papillomavirus–Negative Tonsillar Squamous Cell Carcinoma Under the New 8th AJCC Staging System
title_sort negative prognostic implication of tert promoter mutations in human papillomavirus–negative tonsillar squamous cell carcinoma under the new 8th ajcc staging system
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119516/
https://www.ncbi.nlm.nih.gov/pubmed/33994739
http://dx.doi.org/10.1007/s13193-020-01200-9
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