Oliceridine is Associated with Reduced Risk of Vomiting and Need for Rescue Antiemetics Compared to Morphine: Exploratory Analysis from Two Phase 3 Randomized Placebo and Active Controlled Trials

INTRODUCTION: Use of parenteral opioids is a major risk factor for postoperative nausea and vomiting. Conventional opioids bind to µ-opioid receptors (MOR), stimulate both the G-protein signaling (achieving analgesia); and the β-arrestin pathway (associated with opioid-related adverse effects). Olic...

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Detalles Bibliográficos
Autores principales: Beard, Timothy L., Michalsky, Cathy, Candiotti, Keith A., Rider, Paul, Wase, Linda, Habib, Ashraf S., Demitrack, Mark A., Fossler, Michael J., Viscusi, Eugene R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119517/
https://www.ncbi.nlm.nih.gov/pubmed/33210266
http://dx.doi.org/10.1007/s40122-020-00216-x

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