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Efficacy and Safety of Methylnaltrexone for the Treatment of Opioid-Induced Constipation: A Meta-analysis of Randomized Controlled Trials

INTRODUCTION: Opioid-induced constipation (OIC) is a distressing side effect during opioid analgesia and is mainly mediated by gastrointestinal μ-opioid receptors. Methylnaltrexone, a peripheral μ-opioid receptor antagonist with restricted ability to cross the blood–brain barrier, may alleviate OIC...

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Detalles Bibliográficos
Autores principales:	Zhang, Ying-Ying, Zhou, Rong, Gu, Wan-Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Healthcare 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119523/ https://www.ncbi.nlm.nih.gov/pubmed/33575953 http://dx.doi.org/10.1007/s40122-021-00237-0

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