Cargando…
Outcome of Very Premature Newborn Receiving an Early Second Dose of Surfactant for Persistent Respiratory Distress Syndrome
Background: Infants presenting respiratory distress syndrome (RDS) not responding to surfactant often receive a second instillation. Few studies evaluated the consequences of this second administration. This study aimed at determining the outcome of infants presenting persistent RDS and receiving an...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119642/ https://www.ncbi.nlm.nih.gov/pubmed/33996699 http://dx.doi.org/10.3389/fped.2021.663697 |
_version_ | 1783691897392332800 |
---|---|
author | Greiner, Eva Wittwer, Apolline Albuisson, Eliane Hascoët, Jean-Michel |
author_facet | Greiner, Eva Wittwer, Apolline Albuisson, Eliane Hascoët, Jean-Michel |
author_sort | Greiner, Eva |
collection | PubMed |
description | Background: Infants presenting respiratory distress syndrome (RDS) not responding to surfactant often receive a second instillation. Few studies evaluated the consequences of this second administration. This study aimed at determining the outcome of infants presenting persistent RDS and receiving an early second dose of surfactant. Methods: Infants below 32 weeks' gestation who received a second dose of 100mg/kg of surfactant within the first 72 h of life, were retrospectively involved in this 42 months' study. They were matched to two controls receiving a single dose of 200mg/Kg based upon gender and gestational age. Results: 52/156 infants receiving two doses (Group 2-doses) were significantly more often SGA [22 (42%) vs. 21 (20%) p = 0.04] and outborn [29 (56%) vs. 13 (12%) p = 0.001]. They had received antenatal corticos teroid therapy less often [26 (50%) vs. 89 (86%) p = 0.001] and presented more severe RDS based upon FiO2 level, oxygenation index and radiography. Group 2-doses survival was lower (65.4% vs. 79.6 % p < 0.1) but surviving infants did not have different morbidity than controls. Discussion: Premature newborn receiving a second dose of surfactant had adverse antenatal characteristics, presented more severe RDS and only partially responded to the first dose. Outcomes of surviving infants who received 2 doses of surfactant were comparable to others. |
format | Online Article Text |
id | pubmed-8119642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81196422021-05-15 Outcome of Very Premature Newborn Receiving an Early Second Dose of Surfactant for Persistent Respiratory Distress Syndrome Greiner, Eva Wittwer, Apolline Albuisson, Eliane Hascoët, Jean-Michel Front Pediatr Pediatrics Background: Infants presenting respiratory distress syndrome (RDS) not responding to surfactant often receive a second instillation. Few studies evaluated the consequences of this second administration. This study aimed at determining the outcome of infants presenting persistent RDS and receiving an early second dose of surfactant. Methods: Infants below 32 weeks' gestation who received a second dose of 100mg/kg of surfactant within the first 72 h of life, were retrospectively involved in this 42 months' study. They were matched to two controls receiving a single dose of 200mg/Kg based upon gender and gestational age. Results: 52/156 infants receiving two doses (Group 2-doses) were significantly more often SGA [22 (42%) vs. 21 (20%) p = 0.04] and outborn [29 (56%) vs. 13 (12%) p = 0.001]. They had received antenatal corticos teroid therapy less often [26 (50%) vs. 89 (86%) p = 0.001] and presented more severe RDS based upon FiO2 level, oxygenation index and radiography. Group 2-doses survival was lower (65.4% vs. 79.6 % p < 0.1) but surviving infants did not have different morbidity than controls. Discussion: Premature newborn receiving a second dose of surfactant had adverse antenatal characteristics, presented more severe RDS and only partially responded to the first dose. Outcomes of surviving infants who received 2 doses of surfactant were comparable to others. Frontiers Media S.A. 2021-04-30 /pmc/articles/PMC8119642/ /pubmed/33996699 http://dx.doi.org/10.3389/fped.2021.663697 Text en Copyright © 2021 Greiner, Wittwer, Albuisson and Hascoët. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Greiner, Eva Wittwer, Apolline Albuisson, Eliane Hascoët, Jean-Michel Outcome of Very Premature Newborn Receiving an Early Second Dose of Surfactant for Persistent Respiratory Distress Syndrome |
title | Outcome of Very Premature Newborn Receiving an Early Second Dose of Surfactant for Persistent Respiratory Distress Syndrome |
title_full | Outcome of Very Premature Newborn Receiving an Early Second Dose of Surfactant for Persistent Respiratory Distress Syndrome |
title_fullStr | Outcome of Very Premature Newborn Receiving an Early Second Dose of Surfactant for Persistent Respiratory Distress Syndrome |
title_full_unstemmed | Outcome of Very Premature Newborn Receiving an Early Second Dose of Surfactant for Persistent Respiratory Distress Syndrome |
title_short | Outcome of Very Premature Newborn Receiving an Early Second Dose of Surfactant for Persistent Respiratory Distress Syndrome |
title_sort | outcome of very premature newborn receiving an early second dose of surfactant for persistent respiratory distress syndrome |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119642/ https://www.ncbi.nlm.nih.gov/pubmed/33996699 http://dx.doi.org/10.3389/fped.2021.663697 |
work_keys_str_mv | AT greinereva outcomeofveryprematurenewbornreceivinganearlyseconddoseofsurfactantforpersistentrespiratorydistresssyndrome AT wittwerapolline outcomeofveryprematurenewbornreceivinganearlyseconddoseofsurfactantforpersistentrespiratorydistresssyndrome AT albuissoneliane outcomeofveryprematurenewbornreceivinganearlyseconddoseofsurfactantforpersistentrespiratorydistresssyndrome AT hascoetjeanmichel outcomeofveryprematurenewbornreceivinganearlyseconddoseofsurfactantforpersistentrespiratorydistresssyndrome |