Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation

Human ribonuclease 1 (hRNase 1) is critical to extracellular RNA clearance and innate immunity to achieve homeostasis and host defense; however, whether it plays a role in cancer remains elusive. Here, we demonstrate that hRNase 1, independently of its ribonucleolytic activity, enriches the stem-lik...

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Detalles Bibliográficos
Autores principales: Lee, Heng-Huan, Wang, Ying-Nai, Yang, Wen-Hao, Xia, Weiya, Wei, Yongkun, Chan, Li-Chuan, Wang, Yu-Han, Jiang, Zhou, Xu, Shouping, Yao, Jun, Qiu, Yufan, Hsu, Yi-Hsin, Hwang, Wei-Lun, Yan, Meisi, Cha, Jong-Ho, Hsu, Jennifer L., Shen, Jia, Ye, Yuanqing, Wu, Xifeng, Hou, Ming-Feng, Tseng, Lin-Ming, Wang, Shao-Chun, Pan, Mei-Ren, Yang, Chin-Hua, Wang, Yuan-Liang, Yamaguchi, Hirohito, Pang, Da, Hortobagyi, Gabriel N., Yu, Dihua, Hung, Mien-Chie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119676/
https://www.ncbi.nlm.nih.gov/pubmed/33986289
http://dx.doi.org/10.1038/s41467-021-23075-2

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