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Noninvasive transcranial classification of stroke using a portable eddy current damping sensor

Existing paradigms for stroke diagnosis typically involve computed tomography (CT) imaging to classify ischemic versus hemorrhagic stroke variants, as treatment for these subtypes varies widely. Delays in diagnosis and transport of unstable patients may worsen neurological status. To address these i...

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Autores principales: Shahrestani, Shane, Zada, Gabriel, Chou, Tzu-Chieh, Toy, Brandon, Yao, Bryan, Garrett, Norman, Sanossian, Nerses, Brunswick, Andrew, Shang, Kuang-Ming, Tai, Yu-Chong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119677/
https://www.ncbi.nlm.nih.gov/pubmed/33986450
http://dx.doi.org/10.1038/s41598-021-89735-x
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author Shahrestani, Shane
Zada, Gabriel
Chou, Tzu-Chieh
Toy, Brandon
Yao, Bryan
Garrett, Norman
Sanossian, Nerses
Brunswick, Andrew
Shang, Kuang-Ming
Tai, Yu-Chong
author_facet Shahrestani, Shane
Zada, Gabriel
Chou, Tzu-Chieh
Toy, Brandon
Yao, Bryan
Garrett, Norman
Sanossian, Nerses
Brunswick, Andrew
Shang, Kuang-Ming
Tai, Yu-Chong
author_sort Shahrestani, Shane
collection PubMed
description Existing paradigms for stroke diagnosis typically involve computed tomography (CT) imaging to classify ischemic versus hemorrhagic stroke variants, as treatment for these subtypes varies widely. Delays in diagnosis and transport of unstable patients may worsen neurological status. To address these issues, we describe the development of a rapid, portable, and accurate eddy current damping (ECD) stroke sensor. Copper wire was wound to create large (11.4 cm), medium (4.5 cm), and small (1.5 cm) solenoid coils with varying diameters, with each connected to an inductance-to-digital converter. Eight human participants were recruited between December 15, 2019 and March 15, 2020, including two hemorrhagic stroke, two ischemic stroke, one subarachnoid hemorrhage, and three control participants. Observers were blinded to lesion type and location. A head cap with 8 horizontal scanning paths was placed on the patient. The sensor was tangentially rotated across each row on the patient’s head circumferentially. Consent, positioning, and scanning with the sensor took roughly 15 min from start to end for each participant and all scanning took place at the patient bedside. The ECD sensor accurately classified and imaged each of the varying stroke types in each patient. The sensor additionally detected ischemic and hemorrhagic lesions located deep inside the brain, and its range is selectively tunable during sensor design and fabrication.
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spelling pubmed-81196772021-05-17 Noninvasive transcranial classification of stroke using a portable eddy current damping sensor Shahrestani, Shane Zada, Gabriel Chou, Tzu-Chieh Toy, Brandon Yao, Bryan Garrett, Norman Sanossian, Nerses Brunswick, Andrew Shang, Kuang-Ming Tai, Yu-Chong Sci Rep Article Existing paradigms for stroke diagnosis typically involve computed tomography (CT) imaging to classify ischemic versus hemorrhagic stroke variants, as treatment for these subtypes varies widely. Delays in diagnosis and transport of unstable patients may worsen neurological status. To address these issues, we describe the development of a rapid, portable, and accurate eddy current damping (ECD) stroke sensor. Copper wire was wound to create large (11.4 cm), medium (4.5 cm), and small (1.5 cm) solenoid coils with varying diameters, with each connected to an inductance-to-digital converter. Eight human participants were recruited between December 15, 2019 and March 15, 2020, including two hemorrhagic stroke, two ischemic stroke, one subarachnoid hemorrhage, and three control participants. Observers were blinded to lesion type and location. A head cap with 8 horizontal scanning paths was placed on the patient. The sensor was tangentially rotated across each row on the patient’s head circumferentially. Consent, positioning, and scanning with the sensor took roughly 15 min from start to end for each participant and all scanning took place at the patient bedside. The ECD sensor accurately classified and imaged each of the varying stroke types in each patient. The sensor additionally detected ischemic and hemorrhagic lesions located deep inside the brain, and its range is selectively tunable during sensor design and fabrication. Nature Publishing Group UK 2021-05-13 /pmc/articles/PMC8119677/ /pubmed/33986450 http://dx.doi.org/10.1038/s41598-021-89735-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Shahrestani, Shane
Zada, Gabriel
Chou, Tzu-Chieh
Toy, Brandon
Yao, Bryan
Garrett, Norman
Sanossian, Nerses
Brunswick, Andrew
Shang, Kuang-Ming
Tai, Yu-Chong
Noninvasive transcranial classification of stroke using a portable eddy current damping sensor
title Noninvasive transcranial classification of stroke using a portable eddy current damping sensor
title_full Noninvasive transcranial classification of stroke using a portable eddy current damping sensor
title_fullStr Noninvasive transcranial classification of stroke using a portable eddy current damping sensor
title_full_unstemmed Noninvasive transcranial classification of stroke using a portable eddy current damping sensor
title_short Noninvasive transcranial classification of stroke using a portable eddy current damping sensor
title_sort noninvasive transcranial classification of stroke using a portable eddy current damping sensor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119677/
https://www.ncbi.nlm.nih.gov/pubmed/33986450
http://dx.doi.org/10.1038/s41598-021-89735-x
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