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Fentanyl conjugate vaccine by injected or mucosal delivery with dmLT or LTA1 adjuvants implicates IgA in protection from drug challenge

Fentanyl is a major contributor to the devastating increase in overdose deaths from substance use disorders (SUD). A vaccine targeting fentanyl could be a powerful immunotherapeutic. Here, we evaluated adjuvant and delivery strategies for conjugate antigen vaccination with fentanyl-based haptens. We...

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Detalles Bibliográficos
Autores principales:	Stone, Addison E., Scheuermann, Sarah E., Haile, Colin N., Cuny, Gregory D., Velasquez, Marcela Lopez, Linhuber, Joshua P., Duddupudi, Anantha L., Vigliaturo, Jennifer R., Pravetoni, Marco, Kosten, Therese A., Kosten, Thomas R., Norton, Elizabeth B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119695/ https://www.ncbi.nlm.nih.gov/pubmed/33986280 http://dx.doi.org/10.1038/s41541-021-00329-0

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