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Application of 3D bioprinting in the prevention and the therapy for human diseases

Rapid development of vaccines and therapeutics is necessary to tackle the emergence of new pathogens and infectious diseases. To speed up the drug discovery process, the conventional development pipeline can be retooled by introducing advanced in vitro models as alternatives to conventional infectio...

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Autores principales: Yi, Hee-Gyeong, Kim, Hyeonji, Kwon, Junyoung, Choi, Yeong-Jin, Jang, Jinah, Cho, Dong-Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119699/
https://www.ncbi.nlm.nih.gov/pubmed/33986257
http://dx.doi.org/10.1038/s41392-021-00566-8
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author Yi, Hee-Gyeong
Kim, Hyeonji
Kwon, Junyoung
Choi, Yeong-Jin
Jang, Jinah
Cho, Dong-Woo
author_facet Yi, Hee-Gyeong
Kim, Hyeonji
Kwon, Junyoung
Choi, Yeong-Jin
Jang, Jinah
Cho, Dong-Woo
author_sort Yi, Hee-Gyeong
collection PubMed
description Rapid development of vaccines and therapeutics is necessary to tackle the emergence of new pathogens and infectious diseases. To speed up the drug discovery process, the conventional development pipeline can be retooled by introducing advanced in vitro models as alternatives to conventional infectious disease models and by employing advanced technology for the production of medicine and cell/drug delivery systems. In this regard, layer-by-layer construction with a 3D bioprinting system or other technologies provides a beneficial method for developing highly biomimetic and reliable in vitro models for infectious disease research. In addition, the high flexibility and versatility of 3D bioprinting offer advantages in the effective production of vaccines, therapeutics, and relevant delivery systems. Herein, we discuss the potential of 3D bioprinting technologies for the control of infectious diseases. We also suggest that 3D bioprinting in infectious disease research and drug development could be a significant platform technology for the rapid and automated production of tissue/organ models and medicines in the near future.
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spelling pubmed-81196992021-05-17 Application of 3D bioprinting in the prevention and the therapy for human diseases Yi, Hee-Gyeong Kim, Hyeonji Kwon, Junyoung Choi, Yeong-Jin Jang, Jinah Cho, Dong-Woo Signal Transduct Target Ther Review Article Rapid development of vaccines and therapeutics is necessary to tackle the emergence of new pathogens and infectious diseases. To speed up the drug discovery process, the conventional development pipeline can be retooled by introducing advanced in vitro models as alternatives to conventional infectious disease models and by employing advanced technology for the production of medicine and cell/drug delivery systems. In this regard, layer-by-layer construction with a 3D bioprinting system or other technologies provides a beneficial method for developing highly biomimetic and reliable in vitro models for infectious disease research. In addition, the high flexibility and versatility of 3D bioprinting offer advantages in the effective production of vaccines, therapeutics, and relevant delivery systems. Herein, we discuss the potential of 3D bioprinting technologies for the control of infectious diseases. We also suggest that 3D bioprinting in infectious disease research and drug development could be a significant platform technology for the rapid and automated production of tissue/organ models and medicines in the near future. Nature Publishing Group UK 2021-05-14 /pmc/articles/PMC8119699/ /pubmed/33986257 http://dx.doi.org/10.1038/s41392-021-00566-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Yi, Hee-Gyeong
Kim, Hyeonji
Kwon, Junyoung
Choi, Yeong-Jin
Jang, Jinah
Cho, Dong-Woo
Application of 3D bioprinting in the prevention and the therapy for human diseases
title Application of 3D bioprinting in the prevention and the therapy for human diseases
title_full Application of 3D bioprinting in the prevention and the therapy for human diseases
title_fullStr Application of 3D bioprinting in the prevention and the therapy for human diseases
title_full_unstemmed Application of 3D bioprinting in the prevention and the therapy for human diseases
title_short Application of 3D bioprinting in the prevention and the therapy for human diseases
title_sort application of 3d bioprinting in the prevention and the therapy for human diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119699/
https://www.ncbi.nlm.nih.gov/pubmed/33986257
http://dx.doi.org/10.1038/s41392-021-00566-8
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