Cargando…

IL-23 receptor deficiency results in lower bone mass via indirect regulation of bone formation

The IL-23 receptor (IL-23R) signaling pathway has pleiotropic effects on the differentiation of osteoclasts and osteoblasts, since it can inhibit or stimulate these processes via different pathways. However, the potential role of this pathway in the regulation of bone homeostasis remains elusive. Th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Razawy, Wida, Alves, Celso H., Koedam, Marijke, Asmawidjaja, Patrick S., Mus, Adriana M. C., Oukka, Mohamed, Leenen, Pieter J. M., Visser, Jenny A., van der Eerden, Bram C. J., Lubberts, Erik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119722/ https://www.ncbi.nlm.nih.gov/pubmed/33986359 http://dx.doi.org/10.1038/s41598-021-89625-2

Ejemplares similares

CD4(+)CCR6(+) T cells, but not γδ T cells, are important for the IL‐23R‐dependent progression of antigen‐induced inflammatory arthritis in mice
por: Razawy, Wida, et al.
Publicado: (2019)

The role of IL‐23 receptor signaling in inflammation‐mediated erosive autoimmune arthritis and bone remodeling
por: Razawy, Wida, et al.
Publicado: (2018)

Dendritic Cell-Specific Deletion of β-Catenin Results in Fewer Regulatory T-Cells without Exacerbating Autoimmune Collagen-Induced Arthritis
por: Alves, C. Henrique, et al.
Publicado: (2015)

IL-23 Dependent and Independent Stages of Experimental Arthritis: No Clinical Effect of Therapeutic IL-23p19 Inhibition in Collagen-induced Arthritis
por: Cornelissen, Ferry, et al.
Publicado: (2013)

Interleukin-17A Drives IL-19 and IL-24 Expression in Skin Stromal Cells Regulating Keratinocyte Proliferation
por: Xu, Xiaofei, et al.
Publicado: (2021)

Characterizing memory T helper cells in patients with psoriasis, subclinical, or early psoriatic arthritis using a machine learning algorithm
por: den Braanker, Hannah, et al.
Publicado: (2022)

Loss of Anti-Müllerian Hormone Signaling in Mice Affects Trabecular Bone Mass in a Sex- and Age-Dependent Manner
por: van As, Christiane, et al.
Publicado: (2022)

Interleukin-23 is critical for full-blown expression of a non-autoimmune destructive arthritis and regulates interleukin-17A and RORγt in γδ T cells
por: Cornelissen, Ferry, et al.
Publicado: (2009)

Tensin-3 is involved in osteogenic versus adipogenic fate of human bone marrow stromal cells
por: Zhang, Shuang, et al.
Publicado: (2023)

Zika virus infects human osteoclasts and blocks differentiation and bone resorption
por: Mumtaz, Noreen, et al.
Publicado: (2022)

Lack of IL-17 Receptor A signaling aggravates lymphoproliferation in C57BL/6 lpr mice
por: Corneth, Odilia B. J., et al.
Publicado: (2019)

Lifelong challenge of calcium homeostasis in male mice lacking TRPV5 leads to changes in bone and calcium metabolism
por: van der Eerden, Bram C.J., et al.
Publicado: (2016)

Investigating the role of ASCC1 in the causation of bone fragility
por: Voraberger, Barbara, et al.
Publicado: (2023)

1,25(OH)(2)D(3) and dexamethasone additively suppress synovial fibroblast activation by CCR6(+) T helper memory cells and enhance the effect of tumor necrosis factor alpha blockade
por: Dankers, Wendy, et al.
Publicado: (2018)

Osteocalcin—A Versatile Bone-Derived Hormone
por: Moser, Sarah C., et al.
Publicado: (2019)

Identification of Chloride Intracellular Channel Protein 3 as a Novel Gene Affecting Human Bone Formation
por: Brum, Andrea M, et al.
Publicado: (2017)

HSPB7 oppositely regulates human mesenchymal stromal cell-derived osteogenesis and adipogenesis
por: Zhang, Shuang, et al.
Publicado: (2023)

Meeting report of the 2016 bone marrow adiposity meeting
por: van der Eerden, Bram, et al.
Publicado: (2017)

Inhibition of hypoxia‐induced Mucin 1 alters the proteomic composition of human osteoblast‐produced extracellular matrix, leading to reduced osteogenic and angiogenic potential
por: Jadaun, Pavitra K., et al.
Publicado: (2021)

Identification of small molecules as novel anti-adipogenic compounds based on Connectivity Map
por: Zhang, Shuang, et al.
Publicado: (2022)

Mucin 1 (Muc1) Deficiency in Female Mice Leads to Temporal Skeletal Changes During Aging
por: Brum, Andrea M, et al.
Publicado: (2018)

Upstream Regulators of Fibroblast Growth Factor 23
por: Ratsma, Danielle M. A., et al.
Publicado: (2021)

Animal Models of Bone Loss in Inflammatory Arthritis: from Cytokines in the Bench to Novel Treatments for Bone Loss in the Bedside—a Comprehensive Review
por: Alves, C. Henrique, et al.
Publicado: (2015)

Mechanotransduction in high aspect ratio nanostructured meta-biomaterials: The role of cell adhesion, contractility, and transcriptional factors
por: Modaresifar, Khashayar, et al.
Publicado: (2022)

Interleukin‐17A Is Produced by CD4+ but Not CD8+ T Cells in Synovial Fluid Following T Cell Receptor Activation and Regulates Different Inflammatory Mediators Compared to Tumor Necrosis Factor in a Model of Psoriatic Arthritis Synovitis
por: Xu, Xiaofei, et al.
Publicado: (2020)

Zika virus infection perturbs osteoblast function
por: Mumtaz, Noreen, et al.
Publicado: (2018)

Achieving sustained minimal disease activity with methotrexate in early interleukin 23-driven early psoriatic arthritis
por: den Braanker, Hannah, et al.
Publicado: (2020)

IL-23 Promotes TCR-mediated Negative Selection of Thymocytes through the Upregulation of IL-23 Receptor and RORγt
por: Li, Hao, et al.
Publicado: (2014)

FGF-23 in bone biology
por: Wesseling-Perry, Katherine
Publicado: (2009)

Case Report: Unexplained Mild Hypophosphatemia and Very High Serum FGF23 Concentrations
por: Bosman, Ariadne, et al.
Publicado: (2023)

Neutralizing IL-17 during re-activation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and IL-1
por: Koenders, MI, et al.
Publicado: (2005)

Hydroxychloroquine decreases human MSC‐derived osteoblast differentiation and mineralization in vitro
por: Both, Tim, et al.
Publicado: (2017)

IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis
por: Chabaud, Martine, et al.
Publicado: (2001)

Local IL-17 gene therapy accelerates collagen arthritis with severe bone erosion and rank ligand and rank expression in synovial infiltrate and at bone erosion sites
por: Lubberts, E, et al.
Publicado: (2001)

Dietary Advanced Glycation End-Products (dAGEs) Intake and Bone Health: A Cross-Sectional Analysis in the Rotterdam Study
por: Waqas, Komal, et al.
Publicado: (2020)

IL-23, but not IL-12, plays a critical role in inflammation-mediated bone disorders
por: Xu, Jiajia, et al.
Publicado: (2020)

Guidelines for Biobanking of Bone Marrow Adipose Tissue and Related Cell Types: Report of the Biobanking Working Group of the International Bone Marrow Adiposity Society
por: Lucas, Stephanie, et al.
Publicado: (2021)

Requirement of local synovial IL-17 receptor signaling in the progression of chronic synovitis and bone erosion in arthritis
por: Lubberts, E, et al.
Publicado: (2004)

Fibroblast growth factor 23 and bone mineralisation
por: Guo, Yu-Chen, et al.
Publicado: (2015)

T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine
por: Krausgruber, Thomas, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_42h5k4p6eh8614fmkqol8i0jee