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Study on the neuroprotective effects of Genistein on Alzheimer’s disease
Along with the aging of the world population, the incidence rate of Alzheimer's disease (AD) has been increasing. At present, AD has become one of the most serious problems faced by modern medicine. Studies have shown that estrogen has a positive effect on AD, but estrogen has the side effect o...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119804/ https://www.ncbi.nlm.nih.gov/pubmed/33704934 http://dx.doi.org/10.1002/brb3.2100 |
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author | Duan, Xiaoying Li, Yanshuang Xu, Fei Ding, Hong |
author_facet | Duan, Xiaoying Li, Yanshuang Xu, Fei Ding, Hong |
author_sort | Duan, Xiaoying |
collection | PubMed |
description | Along with the aging of the world population, the incidence rate of Alzheimer's disease (AD) has been increasing. At present, AD has become one of the most serious problems faced by modern medicine. Studies have shown that estrogen has a positive effect on AD, but estrogen has the side effect of leading to tumors. Recent in vivo studies have shown that genistein, one of the selective estrogen receptor modulators (SERMs), can improve brain function through the blood–brain barrier (BBB), antagonize the toxicity of amyloid β‐protein (Aβ), that is, to inhibit neurotoxicity due to aggregation of beta amyloid protein, and have neuroprotective effects. In addition, the use of Gen can avoid the risk of endometrial cancer and breast cancer caused by estrogen therapy while exerting an estrogen‐like effect, which has some potential for the delay and treatment of AD. |
format | Online Article Text |
id | pubmed-8119804 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81198042021-05-20 Study on the neuroprotective effects of Genistein on Alzheimer’s disease Duan, Xiaoying Li, Yanshuang Xu, Fei Ding, Hong Brain Behav Reviews Along with the aging of the world population, the incidence rate of Alzheimer's disease (AD) has been increasing. At present, AD has become one of the most serious problems faced by modern medicine. Studies have shown that estrogen has a positive effect on AD, but estrogen has the side effect of leading to tumors. Recent in vivo studies have shown that genistein, one of the selective estrogen receptor modulators (SERMs), can improve brain function through the blood–brain barrier (BBB), antagonize the toxicity of amyloid β‐protein (Aβ), that is, to inhibit neurotoxicity due to aggregation of beta amyloid protein, and have neuroprotective effects. In addition, the use of Gen can avoid the risk of endometrial cancer and breast cancer caused by estrogen therapy while exerting an estrogen‐like effect, which has some potential for the delay and treatment of AD. John Wiley and Sons Inc. 2021-03-11 /pmc/articles/PMC8119804/ /pubmed/33704934 http://dx.doi.org/10.1002/brb3.2100 Text en © 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Duan, Xiaoying Li, Yanshuang Xu, Fei Ding, Hong Study on the neuroprotective effects of Genistein on Alzheimer’s disease |
title | Study on the neuroprotective effects of Genistein on Alzheimer’s disease |
title_full | Study on the neuroprotective effects of Genistein on Alzheimer’s disease |
title_fullStr | Study on the neuroprotective effects of Genistein on Alzheimer’s disease |
title_full_unstemmed | Study on the neuroprotective effects of Genistein on Alzheimer’s disease |
title_short | Study on the neuroprotective effects of Genistein on Alzheimer’s disease |
title_sort | study on the neuroprotective effects of genistein on alzheimer’s disease |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119804/ https://www.ncbi.nlm.nih.gov/pubmed/33704934 http://dx.doi.org/10.1002/brb3.2100 |
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