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Structural connectivity networks in Alzheimer’s disease and Lewy body disease

OBJECTIVE: We evaluated disruption of the white matter (WM) network related with Alzheimer's disease (AD) and Lewy body disease (LBD), which includes Parkinson's disease and dementia with Lewy bodies. METHODS: We consecutively recruited 37 controls and 77 patients with AD‐related cognitive...

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Autores principales: Baik, Kyoungwon, Yang, Jin‐Ju, Jung, Jin Ho, Lee, Yang Hyun, Chung, Seok Jong, Yoo, Han Soo, Sohn, Young H., Lee, Phil Hyu, Lee, Jong‐Min, Ye, Byoung Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119831/
https://www.ncbi.nlm.nih.gov/pubmed/33792194
http://dx.doi.org/10.1002/brb3.2112
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author Baik, Kyoungwon
Yang, Jin‐Ju
Jung, Jin Ho
Lee, Yang Hyun
Chung, Seok Jong
Yoo, Han Soo
Sohn, Young H.
Lee, Phil Hyu
Lee, Jong‐Min
Ye, Byoung Seok
author_facet Baik, Kyoungwon
Yang, Jin‐Ju
Jung, Jin Ho
Lee, Yang Hyun
Chung, Seok Jong
Yoo, Han Soo
Sohn, Young H.
Lee, Phil Hyu
Lee, Jong‐Min
Ye, Byoung Seok
author_sort Baik, Kyoungwon
collection PubMed
description OBJECTIVE: We evaluated disruption of the white matter (WM) network related with Alzheimer's disease (AD) and Lewy body disease (LBD), which includes Parkinson's disease and dementia with Lewy bodies. METHODS: We consecutively recruited 37 controls and 77 patients with AD‐related cognitive impairment (ADCI) and/or LBD‐related cognitive impairment (LBCI). Diagnoses of ADCI and LBCI were supported by amyloid PET and dopamine transporter PET, respectively. There were 22 patients with ADCI, 19 patients with LBCI, and 36 patients with mixed ADCI/LBCI. We investigated the relationship between ADCI, LBCI, graph theory‐based network measures on diffusion tensor images, and cognitive dysfunction using general linear models after controlling for age, sex, education, deep WM hyperintensities (WMH), periventricular WMH, and intracranial volume. RESULTS: LBCI, especially mixed with ADCI, was associated with increased normalized path length and decreased normalized global efficiency. LBCI was related to the decreased nodal degree of left caudate, which was further associated with broad cognitive dysfunction. Decreased left caudate nodal degree was associated with decreased fractional anisotropy (FA) in the brain regions vulnerable to LBD. Compared with the control group, the LBCI group had an increased betweenness centrality in the occipital nodes, which was associated with decreased FA in the WM adjacent to the striatum and visuospatial dysfunction. CONCLUSION: Concomitant ADCI and LBCI are associated with the accentuation of LBCI‐related WM network disruption centered in the left caudate nucleus. The increase of occipital betweenness centrality could be a characteristic biologic change associated with visuospatial dysfunction in LBCI.
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spelling pubmed-81198312021-05-20 Structural connectivity networks in Alzheimer’s disease and Lewy body disease Baik, Kyoungwon Yang, Jin‐Ju Jung, Jin Ho Lee, Yang Hyun Chung, Seok Jong Yoo, Han Soo Sohn, Young H. Lee, Phil Hyu Lee, Jong‐Min Ye, Byoung Seok Brain Behav Original Research OBJECTIVE: We evaluated disruption of the white matter (WM) network related with Alzheimer's disease (AD) and Lewy body disease (LBD), which includes Parkinson's disease and dementia with Lewy bodies. METHODS: We consecutively recruited 37 controls and 77 patients with AD‐related cognitive impairment (ADCI) and/or LBD‐related cognitive impairment (LBCI). Diagnoses of ADCI and LBCI were supported by amyloid PET and dopamine transporter PET, respectively. There were 22 patients with ADCI, 19 patients with LBCI, and 36 patients with mixed ADCI/LBCI. We investigated the relationship between ADCI, LBCI, graph theory‐based network measures on diffusion tensor images, and cognitive dysfunction using general linear models after controlling for age, sex, education, deep WM hyperintensities (WMH), periventricular WMH, and intracranial volume. RESULTS: LBCI, especially mixed with ADCI, was associated with increased normalized path length and decreased normalized global efficiency. LBCI was related to the decreased nodal degree of left caudate, which was further associated with broad cognitive dysfunction. Decreased left caudate nodal degree was associated with decreased fractional anisotropy (FA) in the brain regions vulnerable to LBD. Compared with the control group, the LBCI group had an increased betweenness centrality in the occipital nodes, which was associated with decreased FA in the WM adjacent to the striatum and visuospatial dysfunction. CONCLUSION: Concomitant ADCI and LBCI are associated with the accentuation of LBCI‐related WM network disruption centered in the left caudate nucleus. The increase of occipital betweenness centrality could be a characteristic biologic change associated with visuospatial dysfunction in LBCI. John Wiley and Sons Inc. 2021-04-01 /pmc/articles/PMC8119831/ /pubmed/33792194 http://dx.doi.org/10.1002/brb3.2112 Text en © 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Baik, Kyoungwon
Yang, Jin‐Ju
Jung, Jin Ho
Lee, Yang Hyun
Chung, Seok Jong
Yoo, Han Soo
Sohn, Young H.
Lee, Phil Hyu
Lee, Jong‐Min
Ye, Byoung Seok
Structural connectivity networks in Alzheimer’s disease and Lewy body disease
title Structural connectivity networks in Alzheimer’s disease and Lewy body disease
title_full Structural connectivity networks in Alzheimer’s disease and Lewy body disease
title_fullStr Structural connectivity networks in Alzheimer’s disease and Lewy body disease
title_full_unstemmed Structural connectivity networks in Alzheimer’s disease and Lewy body disease
title_short Structural connectivity networks in Alzheimer’s disease and Lewy body disease
title_sort structural connectivity networks in alzheimer’s disease and lewy body disease
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119831/
https://www.ncbi.nlm.nih.gov/pubmed/33792194
http://dx.doi.org/10.1002/brb3.2112
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